Methyl2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate
- Product Name
- Methyl2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate
- CAS No.
- 1083168-93-7
- Chemical Name
- Methyl2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate
- Synonyms
- Methyl 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);2-Methoxy-3-(carbomethoxy)pyridine-5-boronic acid, pinacol ester;6-Methoxy-5-(methoxycarbonyl)pyridine-3-boronic Acid Pinacol Ester;2-Methoxy-3-(carbomethoxy)pyridine-5-boronic acid, pinacol ester 95+%;Methyl2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate;METHYL 2-(METHYLOXY)-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINECARBOXYLATE;2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-Pyridinecarboxylic acid methyl ester;3-Pyridinecarboxylic acid, 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester
- CBNumber
- CB42490733
- Molecular Formula
- C14H20BNO5
- Formula Weight
- 293.12
- MOL File
- 1083168-93-7.mol
Methyl2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Powder
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M329113
- Product name
- 2-Methoxy-3-(carbomethoxy)pyridine-5-boronicacid,pinacolester
- Packaging
- 25mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- OR361326
- Product name
- 2-Methoxy-3-(carbomethoxy)pyridine-5-boronic acid, pinacol ester
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $96
- Updated
- 2021/12/16
- Product number
- Z7215
- Product name
- 2-Methoxy-3-(carbomethoxy)pyridine-5-boronicacidpinacolester
- Packaging
- 100mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- OR361326
- Product name
- 2-Methoxy-3-(carbomethoxy)pyridine-5-boronic acid, pinacol ester
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $154
- Updated
- 2021/12/16
- Product number
- 091498
- Product name
- Methyl 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $326
- Updated
- 2021/12/16
Methyl2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate Chemical Properties,Usage,Production
Synthesis
122433-41-4
73183-34-3
1083168-93-7
General procedure for the synthesis of methyl 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate from 5-bromo-2-methoxynicotinic acid methyl ester and pinacol ester of bisboronic acid: to a dry flask were added 5-bromo-2-methoxynicotinic acid methyl ester (0.5 g, 2.0 mmol), pinacol ester of bisboronic acid (0.61 g, 2.4 mmol) and Pd(dppf)Cl2 (82 mg, 0.10 mmol). Subsequently, potassium acetate (0.6 g, 6.0 mmol) was added directly to the flask. The flask was evacuated and backfilled three times with nitrogen. Anhydrous N,N-dimethylformamide (10.0 mL) was added and the reaction mixture was heated in an oil bath at 80°C overnight. After completion of the reaction, the mixture was evaporated to dryness and the residue was dissolved in ethyl acetate (10 mL) and washed with water (10 mL). The organic phase was dried with anhydrous sodium sulfate and then evaporated to dryness. The crude product was purified by silica gel column chromatography using a hexane solution of 0-70% ethyl acetate as eluent to give the target product (0.36 g in 72% yield).The calculated value for ESI-MS m/z was 249.11, and the measured value was 250.3 ([M+H]+).The HPLC retention time was 1.84 min.
References
[1] Patent: WO2008/141119, 2008, A2. Location in patent: Page/Page column 104
Methyl2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
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