Voclosporin

ChemicalBook > CAS DataBase List > Voclosporin

Product Name: Voclosporin
CAS No.: 515814-01-4
Chemical Name: Voclosporin
Synonyms: Voclosporine;Voclosporin (ISAtx-247);Lx211;R 1524;Luveniq;Isatx247;Isatx-247;Isatx 247;Voclosporin;Volciclosporin
CBNumber: CB42496083
Molecular Formula: C63H111N11O12
Formula Weight: 1214.65
MOL File: 515814-01-4.mol

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Voclosporin Property

Boiling point:: 1303.8±65.0 °C(Predicted)
Density: 1.016±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Benzene (Slightly), Methanol (Slightly)
pka: 13.32±0.70(Predicted)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3108
Product name: Voclosporin
Purity: ≥95% (HPLC)
Packaging: 1MG
Price: $146
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3108
Product name: Voclosporin
Purity: ≥95% (HPLC)
Packaging: 5MG
Price: $596
Updated: 2024/03/01

ChemScene

Product number: CS-0026210
Product name: Voclosporin
Purity: 99.20%
Packaging: 5mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0026210
Product name: Voclosporin
Purity: 99.20%
Packaging: 10mg
Price: $950
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0026527
Product name: VOCLOSPORIN
Purity: 95.00%
Packaging: 2.5MG
Price: $952.88
Updated: 2021/12/16

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Voclosporin Chemical Properties,Usage,Production

Description

Voclosporin, a structurally similar analogue of cyclosporin A, is a new type of calcineurin inhibitor. It has been modified to increase its activity by 3-4 times and exhibits a dual and synergistic mechanism. This drug works by blocking the expression of IL-2 and T cell-mediated immune response, stabilizing renal podocytes. Compared to cyclosporin, voclosporin has the advantage of having less impact on cholesterol and triglycerides and a lower risk of diabetes. In February 2021, vorcyclosporine was approved by the FDA for use in combination immunosuppressive regimens in adult patients with active, lupus nephritis.

Uses

A new agent for the treatment of noninfectious uveitis. Uveitis is an inflammatory, putative Th1-mediated autoimmune disease that affects various parts of the eye and is a leading cause of visual loss. Voclosporin, a rationally designed novel calcineurin inhibitor, exhibits a favorable safety profile, a strong correlation between pharmacokinetic and pharmacodynamic response, and a wide therapeutic window. Immunosuppressant.

Definition

ChEBI: Voclosporin is a homodetic cyclic peptide. It is a semi-synthetic calcineurin (CN) inhibitor that exhibits potent immunosuppressive activity.

Clinical Use

Voclosporin (Lupkynis(TM)) is an oral calcineurin inhibitor immunosuppressant that is being developed by Aurinia Pharmaceuticals. In January 2021, based on positive results from the pivotal phases II and III trials, oral voclosporin received its first approval in the USA for use in combination with a background immunosuppressive therapy regimen for adults with active lupus nephritis.

References

1. Voclosporin: First Approval DOI: 10.1007/s40265-021-01488-z
2. Voclosporin: A Novel Calcineurin Inhibitor for the Treatment of Lupus Nephritis DOI: 10.1177/10600280221075331

Voclosporin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Voclosporin manufacturers

Dideu Industries Group Limited

Product: Voclosporin 515814-01-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-17

515814-01-4, VoclosporinRelated Search:

Isatx 247

Isatx247

Isatx-247

Luveniq

Lx211

R 1524

Voclosporin

Voclosporin [usan]

Cyclosporin A, 6-[(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6,8-nonadienoic acid]-

Voclosporine

Voclosporin USP/EP/BP

Voclosporin (ISAtx-247)

(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhepta-4,6-dien-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone

Volciclosporin

515814-01-4

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