5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole
- Product Name
- 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole
- CAS No.
- 107862-65-7
- Chemical Name
- 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole
- Synonyms
- 4H,5H,6H-pyrrolo[1,2-b]pyrazole;5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole;4H-Pyrrolo[1,2-b]pyrazole, 5,6-dihydro-
- CBNumber
- CB42499064
- Molecular Formula
- C6H8N2
- Formula Weight
- 108.14
- MOL File
- 107862-65-7.mol
5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole Property
- Boiling point:
- 206℃
- Density
- 1.23
- Flash point:
- 78℃
- pka
- 2.85±0.20(Predicted)
- InChI
- InChI=1S/C6H8N2/c1-2-6-3-4-7-8(6)5-1/h3-4H,1-2,5H2
- InChIKey
- LQKUERRPRLVSLZ-UHFFFAOYSA-N
- SMILES
- N1=CC=C2CCCN12
Safety
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D450500
- Product name
- 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole
- Packaging
- 500mg
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- CS-0054078
- Product name
- 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole
- Packaging
- 1g
- Price
- $1050
- Updated
- 2021/12/16
- Product number
- FD142139
- Product name
- 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole
- Packaging
- 50mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FD142139
- Product name
- 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole
- Packaging
- 100mg
- Price
- $96
- Updated
- 2021/12/16
- Product number
- FD142139
- Product name
- 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole
- Packaging
- 250mg
- Price
- $192.5
- Updated
- 2021/12/16
5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole Chemical Properties,Usage,Production
Uses
5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole is used in the preparation of withasomnine molecules, pyrazole alkaloids, for their application towards antiinflammatory compounds and analgesics.
Synthesis
174790-34-2
107862-65-7
3-(3-Chloropropyl)-1H-pyrazole (500 mg, 3.5 mmol) was used as a starting material and dissolved in a mixed solvent of isopropanol/water (5 mL/1 mL) and potassium hydroxide (389 mg, 6.9 mmol) was added. The reaction mixture was stirred at 90 °C for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and extracted with dichloromethane (3 x 20 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. Purification of the residue by silica gel column chromatography (petroleum ether: ethyl acetate = 6:1 to 2:1) afforded 5,6-dihydro-4H-pyrrolo[1,2-B]pyrazole (150 mg, 39.6% yield) as a brown oil.LC-MS (ESI) detection: 109 [M + 1].
References
[1] Patent: WO2017/35353, 2017, A1. Location in patent: Paragraph 0953
[2] Tetrahedron Letters, 1996, vol. 37, # 7, p. 1095 - 1096
[3] Patent: WO2013/52394, 2013, A1. Location in patent: Paragraph 00248
[4] Tetrahedron, 2013, vol. 69, # 34, p. 7139 - 7146
[5] Patent: WO2013/192125, 2013, A1. Location in patent: Page/Page column 135
5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole manufacturers
- Product
- 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole 107862-65-7
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-12