ChemicalBook > CAS DataBase List > 1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester

1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester

Application

Product Name: 1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester
CAS No.: 864770-82-1
Chemical Name: 1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester
Synonyms: 1-Boc-3-methylindazole-5-boronic Acid Pinacol Ester;1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester;1-N-Boc-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3-Methyl-indazole;(1-(TERT-BUTOXYCARBONYL)-3-METHYL-1H-INDAZOL-5-YL)BORONIC ACID PINACOL ESTER;3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate;Tert-butyl 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indazole-1-carboxylate;tert-butyl 3-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate;3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylic acid 1,1-dimethylethyl ester;1H-Indazole-1-carboxylic acid, 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester
CBNumber: CB42499635
Molecular Formula: C19H27BN2O4
Formula Weight: 358.24
MOL File: 864770-82-1.mol

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1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester Property

Boiling point:: 476℃
Density: 1.12
Flash point:: 242℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to off-white Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB144070
Product name: tert-Butyl 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate
Packaging: 100mg
Price: $85
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144070
Product name: tert-Butyl 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate
Packaging: 250mg
Price: $170
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H60-1-FY
Product name: 1-N-Boc-3-methyl-indazole-5-boronic acid, pinacol ester
Purity: 97%
Packaging: 250mg
Price: $240
Updated: 2021/12/16

AK Scientific

Product number: 3554AC
Product name: 1-N-Boc-3-Methylindazole-5-boronicacidpinacolester
Packaging: 250mg
Price: $279
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144070
Product name: tert-Butyl 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate
Packaging: 500mg
Price: $295
Updated: 2021/12/16

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1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester Chemical Properties,Usage,Production

Application

1-N-BOC-3-methylindazole-5-boronic acid pinacol ester is an organic synthesis intermediate and pharmaceutical intermediate that can be used in laboratory research and development processes and chemical production processes.

Synthesis

552331-49-4

73183-34-3

864770-82-1

Potassium acetate (4.73 g, 48.3 mmol) and Pd(dppf)Cl2 (0.66 g, 0.81 mmol) in anhydrous DMF (60 mL) were added to tert-butyl 5-bromo-3-methyl-1H-indazole-1-carboxylate (5.00 g, 16.1 mmol) and pinacol ester of bisboronic acid (4.49 g, 17.7 mmol). The mixture was placed in a vial with a rubber-lined screw cap and degassed by three vacuum/nitrogen cycles. Subsequently, the suspension was heated with stirring at 100 °C for 2 h under nitrogen protection. Upon completion of the reaction, the mixture was cooled to room temperature, mixed with saturated aqueous sodium bicarbonate solution (100 mL) and extracted with ethyl acetate (2 x 150 mL). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give the crude product. The crude product was purified by silica gel column chromatography using gradient elution with ethyl acetate/hexane (0% to 15%) to afford the target product tert-butyl 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate as an oil (5.55 g, 96% yield).LCMS (+APCI) m/z. 499 (M+H).

References

[1] Patent: US2008/153813, 2008, A1. Location in patent: Page/Page column 24
[2] Patent: WO2005/85227, 2005, A1. Location in patent: Page/Page column 37; 76
[3] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 2, p. 673 - 678
[4] Patent: US2008/153813, 2008, A1. Location in patent: Page/Page column 22-23
[5] Patent: US2008/153813, 2008, A1. Location in patent: Page/Page column 23

1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester manufacturers

Career Henan Chemical Co

Product: 1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester 864770-82-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%-100%
Supply Ability: 1
Release date: 2018-08-12

864770-82-1, 1-N-Boc-3-methyl-indazole-5-boronic acid pinacol esterRelated Search:

1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester

3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate

3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylic acid 1,1-dimethylethyl ester

tert-butyl 3-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate

(1-(TERT-BUTOXYCARBONYL)-3-METHYL-1H-INDAZOL-5-YL)BORONIC ACID PINACOL ESTER

1-N-Boc-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3-Methyl-indazole

Tert-butyl 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indazole-1-carboxylate

1H-Indazole-1-carboxylic acid, 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester

1-Boc-3-methylindazole-5-boronic Acid Pinacol Ester

864770-82-1