ChemicalBook > CAS DataBase List > 4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one

4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one

Product Name
4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one
CAS No.
41931-13-9
Chemical Name
4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one
Synonyms
LCS-1;LCS-1 (LCS1);SOD1 Inhibitor, LCS-1;4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one;4,5-dichloro-2-(3-methylphenyl)pyridazin-3-one;4,5-Dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone;SOD1 Inhibitor, LCS-1 - CAS 41931-13-9 - Calbiochem;3(2H)-Pyridazinone, 4,5-dichloro-2-(3-methylphenyl)-;4,5-dichloro-2-(3-Methylphenyl)-2,3-dihydropyridazin-3-one;4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one ISO 9001：2015 REACH
CBNumber
CB42500078
Molecular Formula
C11H8Cl2N2O
Formula Weight
255.1
MOL File
41931-13-9.mol
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4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one Property

Melting point:
117 °C
Boiling point:
339.6±52.0 °C(Predicted)
Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble10mg/mL (clear solutikon, warmed)
form 
White solid
pka
-3.29±0.60(Predicted)
color 
white to beige
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Safety

Hazard Codes 
T,Xi
Risk Statements 
25-36
Safety Statements 
26-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0466
Product name
LCS-1
Purity
≥98% (HPLC)
Packaging
5mg
Price
$148
Updated
2025/07/31
Sigma-Aldrich
Product number
567417
Product name
SOD1 Inhibitor, LCS-1
Packaging
10mg
Price
$202
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0466
Product name
LCS-1
Purity
≥98% (HPLC)
Packaging
25mg
Price
$584
Updated
2025/07/31
TRC
Product number
L270003
Product name
LCS1
Packaging
5mg
Price
$80
Updated
2021/12/16
TRC
Product number
L270003
Product name
LCS1
Packaging
10mg
Price
$125
Updated
2021/12/16
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4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one Chemical Properties,Usage,Production

Uses

LCS 1 is an inhibitor of Superoxide Dismutase 1 (SOD1).

Biochem/physiol Actions

LCS-1 is an inhibitor of superoxide dismutase (SOD1). LCS-1 inhibits the proliferation of lung adendocarcinoma cell lines.

in vivo

LCS-1 (20 mg/kg; i.p. every other day for 14 days) inhibits MM growth and prolongs host survival in MM.1S-bearing mice[3].

Animal Model:5-week-old female CB17 SCID mice (MM.1S tumors volume=100 mm3)[3]
Dosage:20 mg/kg (diluted in saline)
Administration:Intraperitoneal injections; treated on an every other day schedule for 14 days
Result:Inhibited MM growth and prolongs host survival.

IC 50

SOD1: 1.07 μM (IC50)

4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one Suppliers

China 49 United States 7 USA 1 Global 57
Nanjing Norris-Pharm Technology Co., Ltd
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18652989687
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+86-25-52131256
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sales@norris-pharm.com
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China
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SynAsst Chemical.
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021-60343070
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021-35122006
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China
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Shanghai Yolne Chemical Co., Ltd.
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934678158@qq.com
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Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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3008007409@qq.com
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Chengdu Senior Pharma Technology Co.Ltd.
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+86-0838-2319818 +86-15982001943
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seniorpharma@163.com
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China
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Shanghai Rlavie Technology Co., Ltd.
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21-67759270 17717059219
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sales@rlavie.com
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Aikon International Limited
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025-66061636 18013972705
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(3)02557626880
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qqyang@aikonchem.com
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Dideu Industries Group Limited
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+86-29-89586680 +86-15129568250
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1026@dideu.com
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View Lastest Price from 4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one manufacturers

Shanghai Rlavie Technology Co ltd
Product
4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one 41931-13-9
Price
US $0.00/KG
Min. Order
1g
Purity
99%minHPLC
Supply Ability
10kgs/month
Release date
2021-11-05
Dideu Industries Group Limited
Product
4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one 41931-13-9
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-11-09

41931-13-9, 4,5-Dichloro-2-m-tolylpyridazin-3(2H)-oneRelated Search:

4,5-Dichloro-2-(4-Chlorophenyl)-2,3-Dihydropyridazin-3-One 4,5-DICHLORO-2-[4-(TRIFLUOROMETHYL)PHENYL]PYRIDAZIN-3(2H)-ONE 4,5-dichloro-2-(1-methylethyl)-3(2H)-Pyridazinone

  • 4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one
  • 4,5-dichloro-2-(3-Methylphenyl)-2,3-dihydropyridazin-3-one
  • 4,5-Dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone
  • LCS-1
  • SOD1 Inhibitor, LCS-1
  • 4,5-dichloro-2-(3-methylphenyl)pyridazin-3-one
  • LCS-1 (LCS1)
  • SOD1 Inhibitor, LCS-1 - CAS 41931-13-9 - Calbiochem
  • 3(2H)-Pyridazinone, 4,5-dichloro-2-(3-methylphenyl)-
  • 4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one ISO 9001：2015 REACH
  • 41931-13-9