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BMS-690514

Product Name
BMS-690514
CAS No.
859853-30-8
Chemical Name
BMS-690514
Synonyms
CS-472;BMS-690514;BMS-6690514;BMS690514/BMS-690514;BMS-690514(BMS-6690514);(3R,4R)-4-Amino-1-[[4-[(3...;(3R,4R)-4-Amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo-[2,1-f][1,2,4]triazin-5-yl]methyl]piperi;(3R,4R)-4-amino-1-[[4-(3-methoxyanilino)pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol;(3R,4R)-4-Amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo-[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin;(3R,4R)-4-Amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol
CBNumber
CB42501404
Molecular Formula
C19H24N6O2
Formula Weight
368.43
MOL File
859853-30-8.mol
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BMS-690514 Property

Density 
1.41
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
14.41±0.40(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0244
Product name
BMS-690514
Purity
99.89%
Packaging
2mg
Price
$192
Updated
2021/12/16
ApexBio Technology
Product number
A3256
Product name
BMS-690514
Packaging
2mg
Price
$252
Updated
2021/12/16
ChemScene
Product number
CS-0244
Product name
BMS-690514
Purity
99.89%
Packaging
5mg
Price
$288
Updated
2021/12/16
ApexBio Technology
Product number
A3256
Product name
BMS-690514
Packaging
5mg
Price
$378
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611490
Product name
BMS-690514
Packaging
5mg
Price
$399.5
Updated
2021/12/16
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BMS-690514 Chemical Properties,Usage,Production

Uses

BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR; has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.

in vivo

BMS-690514 has been shown to be efficacious in a broad spectrum of tumor xenografts. At doses that are efficacious and well tolerated in the animal models, BMS-690514 inhibits tumor cell proliferation and tumor blood flow[1]. The oral bioavailability of BMS-690514 is 78% in mice, 100% in rats, 8% in monkeys, and 29% in dogs. BMS-690514 is able to cross the blood–brain barrier with a brain-to-plasma ratio of 1. The preclinical ADME properties of BMS-690514 suggest good oral bioavailability in humans and metabolism by multiple pathways including oxidation and glucuronidation[2].

IC 50

EGFR: 5 nM (IC50); HER2: 20 nM (IC50); HER4: 60 nM (IC50); VEGFR1; VEGFR2; VEGFR3

References

[1] Wong TW, et al. Antitumor and antiangiogenic activities of BMS-690514, an inhibitor of human EGF and VEGF receptor kinase families. Clin Cancer Res. 2011 Jun 15;17(12):4031-41. DOI:10.1158/1078-0432.CCR-10-3417
[2] Marathe P, et al. Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2. J Pharm Sci. 2010 Aug;99(8):3579-93. DOI:10.1002/jps.22099

BMS-690514 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS-690514 Suppliers

China 56 France 1 India 1 United States 12 Global 70
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
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United States
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12952
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65
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
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58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
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60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
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58
ApexBio Technology
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Fax
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Email
sales@apexbt.com
Country
United States
ProdList
6251
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58
Creative Enzymes
Tel
--
Fax
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Email
info@creative-enzymes.com
Country
United States
ProdList
6057
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58
Combi-Blocks Inc.
Tel
--
Fax
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Email
sales@combi-blocks.com
Country
United States
ProdList
6618
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Matrix Scientific
Tel
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Fax
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Email
sales@matrixscientific.com
Country
United States
ProdList
6632
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View Lastest Price from BMS-690514 manufacturers

Career Henan Chemical Co
Product
BMS-690514 859853-30-8
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2019-12-31

859853-30-8, BMS-690514Related Search:


  • BMS-690514
  • (3R,4R)-4-Amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol
  • BMS-6690514
  • (3R,4R)-4-amino-1-[[4-(3-methoxyanilino)pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol
  • (3R,4R)-4-Amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo-[2,1-f][1,2,4]triazin-5-yl]methyl]piperi
  • 3-Piperidinol, 4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]-, (3R,4R)-
  • (3R,4R)-4-Amino-1-[[4-[(3...
  • BMS-690514(BMS-6690514)
  • BMS690514/BMS-690514
  • (3R,4R)-4-Amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo-[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin
  • CS-472
  • inhibit,ErbB-1,BMS690514,Vascular endothelial growth factor receptor,Epidermal growth factor receptor,Inhibitor,EGFR,BMS 690514,VEGFR,BMS-690514,HER1
  • 859853-30-8