SU 16f

ChemicalBook > CAS DataBase List > SU 16f

Product Name: SU 16f
CAS No.: 251356-45-3
Chemical Name: SU 16f
Synonyms: SU 16f;PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem;(Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid;5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoicacid;1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-;3-{2,4-dimethyl-5-[(2-oxo-6-phenyl-2,3-dihydro-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid
CBNumber: CB42501833
Molecular Formula: C24H22N2O3
Formula Weight: 386.44
MOL File: 251356-45-3.mol

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SU 16f Property

Boiling point:: 661.7±55.0 °C(Predicted)
Density: 1.292±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: Soluble to 100 mM in DMSO
form: Dark orange solid
pka: 4?+-.0.10(Predicted)
color: Yellow to orange

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 521237
Product name: PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem
Packaging: 5mg
Price: $294
Updated: 2023/06/20

Cayman Chemical

Product number: 19555
Product name: SU 16f
Purity: ≥98%
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 19555
Product name: SU 16f
Purity: ≥98%
Packaging: 5mg
Price: $129
Updated: 2024/03/01

Cayman Chemical

Product number: 19555
Product name: SU 16f
Purity: ≥98%
Packaging: 10mg
Price: $238
Updated: 2024/03/01

Tocris

Product number: 3304
Product name: SU16f
Purity: ≥98%(HPLC)
Packaging: 10
Price: $233
Updated: 2021/12/16

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SU 16f Chemical Properties,Usage,Production

Uses

SU 16f is used in the synthetic preparation of [(Dihydrooxoindolylidene)methyl]pyrrolepropanoic Acid as a tyrosine kinase inhibitor.

General Description

A cell-permeable indolinone compound that acts as a potent, ATP site-targeting PDGFR inhibitor (IC₅₀ = 10 nM against PDGFRβ), while affecting Flk-1/KDR/ VEGFR2, FGFR1, and EGFR only at much higher concentrations (IC₅₀ = 0.14, 2.29, and >100 μM, respectively). Reported to selectively inhibit PDGFβ- over EGF-stimulated proliferation in EGFR-expressing NIH 3T3 cultures (IC₅₀ = 0.11 and 21.9 μM, respectively) and exhibit much weaker potency against the proliferation of HUVEC cells upon FGF or VEGF stimulation (IC₅₀ = 10 μM).

storage

Store at RT

SU 16f Preparation Products And Raw materials

Raw materials

Preparation Products

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251356-45-3, SU 16fRelated Search:

5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoicacid

(Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid

SU 16f

PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem

1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-

3-{2,4-dimethyl-5-[(2-oxo-6-phenyl-2,3-dihydro-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid

251356-45-3

Angiogenesis and Metastasis