Capecitabine-2',3'-cyclic Carbonate

Product Name: Capecitabine-2',3'-cyclic Carbonate
CAS No.: 921769-65-5
Chemical Name: Capecitabine-2',3'-cyclic Carbonate
Synonyms: Capecitabine USP RC C;Capecitabine USP IMp.C;Capecitabine EP Impurity F;Capecitabine-2',3'-cyclic Carbonate;Capacitabine USP Related Compound C;Capecitabine USP Related Compound C;2-hydroxy-11-(methylthio)butanamide;CAPECITABINE related substance USP C;Capecitabine-2'',3''-cyclic Carbonate;Capecitabine-2',3'-cyclic carbonate, 98.5%
CBNumber: CB42503059
Molecular Formula: C16H20FN3O7
Formula Weight: 385.34
MOL File: 921769-65-5.mol

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Capecitabine-2',3'-cyclic Carbonate Property

Melting point:: 68-69°C
Density: 1.58±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Sparingly), Methanol (Slightly, Heated)
form: Solid
pka: 5.34±0.40(Predicted)
color: White
Major Application: pharmaceutical (small molecule)
InChIKey: VTAMAYSBXXKQPB-IZSYJUOESA-N
SMILES: FC1=CN(C(=O)N=C1NC(=O)OCCCCC)[C@@H]2O[C@@H](C3OC(=O)O[C@@H]32)C

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Safety

Safety Statements: 24/25
WGK Germany: WGK 3
HS Code: 29349990
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: C175660
Product name: Capecitabine-2'',3''-cyclicCarbonate
Packaging: 5mg
Price: $130
Updated: 2021/12/16

TRC

Product number: C175660
Product name: Capecitabine-2'',3''-cyclicCarbonate
Packaging: 25mg
Price: $435
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0046145
Product name: CAPECITABINE EP IMPURITY C
Purity: 95.00%
Packaging: 5MG
Price: $456.76
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NC16644
Product name: Capecitabine 2',3'-cyclic carbonate
Packaging: 25mg
Price: $700
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NC16644
Product name: Capecitabine 2',3'-cyclic carbonate
Packaging: 5mg
Price: $160
Updated: 2021/12/16

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Capecitabine-2',3'-cyclic Carbonate Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Capecitabine-2'',3''-cyclic Carbonate (Capecitabine EP Impurity F) is a capecitabine related compound C is an impurity in Capecitabine (C175650), an antineoplastic agent. Capecitabine is a prodrug of Doxifluridine (D556750).

Uses

Capecitabine related compound C.

Synthesis

Weighing 5-fluorocytosine 25.0g in 500ml three-necked bottle, to which added 55ml of toluene, hexamethyldisilamine 2ml, 110 heating reflux 6.5h, after the completion of the reaction, concentrated reaction solution. Then add 26.0g of triacetyl ribose and 200ml of dichloromethane to reduce the temperature to -10~0, add 20ml of tin tetrachloride and 50ml of dichloromethane mixed solution dropwise, react for 8h, adjust the pH with aqueous sodium bicarbonate to 4~5, and then extract with dichloromethane for two times, merge the organic phases, and then obtain the condensate by evaporation and concentration.
Add n-pentyl chloroformate 30 mlg, dichloromethane 100 ml, pyridine 20 ml to the condensate, react at -15 for 2h, adjust pH4-6 with hydrochloric acid, stratify, and concentrate the organic layer to obtain oil.
Add 100ml of acetic anhydride to the oil, heat and reflux for 15h, evaporate the acetic anhydride under reduced pressure, add 450ml of water and 400ml of trichloromethane to extract, 200ml of water washed three times. The trichloromethane layer was concentrated to obtain an oil, which was extracted by dichloromethane and concentrated to obtain an oil.
Finally, it was separated on a silica gel column eluting with ethyl acetate and petroleum ether 1:1, and the final product was collected, concentrated and dried to obtain the white-like compound with high purity.1H-NMR (400MHz, CDCl3)δ0.1.0~1.07 (t, 3h), 1.20(t,3H), 1.29(d,2H), 1.34~1.36(d,4H), 1.57(d,4H), 1.57(d,4H), 1.57(d,4H), 1.57(d,4H), 1.57(d,4H), 1.57(d,4H). ), 1.57 (d,2H), 4.08 (d,2H), 4.55 (d,2H), 4.59~4.60 (s,2H), 5.94 (d,2H), 6.93 (m,1H) 8.0 (s,1H). Liquid phase purity 99% .

Capecitabine-2',3'-cyclic Carbonate Preparation Products And Raw materials

Raw materials

Preparation Products

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Capecitabine-2',3'-cyclic Carbonate Suppliers

Canada 1 China 75 India 9 United Kingdom 1 United States 7 Global 93

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5645
Advantage: 65

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-86818997 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2974
Advantage: 60

Quality Control Solutions Ltd.

Tel: 0755-66853366 13670046396
Fax: 0755-28363542
Email: orders@qcsrm.com
Country: China
ProdList: 18421
Advantage: 56

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

Tonichem Pharmaceutical Technology Co., Ltd.

Tel: +86 (0752) 222-7171, +86 15815821171
Fax: +86 (0752) 222-6171
Country: China
ProdList: 1120
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

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View Lastest Price from Capecitabine-2',3'-cyclic Carbonate manufacturers

Moxin Chemicals

Product: Capecitabine Impurity 921769-65-5
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98
Supply Ability: 100000000
Release date: 2024-12-09

Career Henan Chemical Co

Product: Capecitabine-2',3'-cyclic Carbonate 921769-65-5
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-13

921769-65-5, Capecitabine-2',3'-cyclic CarbonateRelated Search:

3'-O-(5'-Deoxy-α-D-ribofuranosyl) Capecitabine CAPECITABINE related substance USP 5'-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine Capecitabine

Capecitabine Related Compound C/Capecitabine-2',3'-cyclic carbonate

pentyl N-[1-[(3aS,4R,6R)-6-methyl-2-oxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate

Capecitabine impurity 6/Capecitabine EP Impurity F/Capecitabine USP Related Compound C/Capecitabine-2',3'-cyclic carbonate

Capecitabine-2',3'-cyclic Carbonate

CAPECITABINE related substance USP C

Capecitabine USP RC C

pentyl (5-fluoro-1-((3aR,4R,6R,6aR)-6-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

Capecitabine-2',3'-cyclic carbonate, 98.5%

Capecitabine EP Impurity F

Capecitabine Impurity 8(Capecitabine EP Impurity F)

5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine Cyclic 2',3'-Carbonate

Capecitabine USP IMp.C

Cytidine, 5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-, cyclic 2',3'-carbonate

Capecitabine EP Impurity F/ Capecitabine Related Compund C (2,3-O-Carbonyl-Capecitabine)

Capacitabine USP Related Compound C

Capecitabine EP Impurity F (Capecitabine USP Related Compound C)

Capecitabine USP Related Compound C

5'-Deoxy-5-fluoro-2',3'-O-(oxomethylene)-N-[(pentyloxy)carbonyl]cytidine

2-hydroxy-11-(methylthio)butanamide

2',3'-O-Carbonyl-5'-deoxy-5-fluoro-N?-(pentyloxycarbonyl)cytidine

Capecitabine-2'',3''-cyclic Carbonate

Capecitabine-2'',3''-cyclic Carbonate, 10 mM in DMSO

2',3'-O-Carbonyl-5'-deoxy-5-fluoro-N′-(pentyloxycarbonyl)cytidine

921769-65-5

2450971-05-7

27303-40-9

C16H20FN3O7

38534

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