ChemicalBook > CAS DataBase List > 2-Fluoro-6-methylphenylboronic acid

2-Fluoro-6-methylphenylboronic acid

Product Name: 2-Fluoro-6-methylphenylboronic acid
CAS No.: 887471-69-4
Chemical Name: 2-Fluoro-6-methylphenylboronic acid
Synonyms: 2-iodo-3-(methoxymethyl)pyridine;2-Fluoro-6-methylphenylboronic acid;(2-Fluoro-6-methylphenyl)boronic acid 97%;Boronic acid, B-(2-fluoro-6-methylphenyl)-;(2-fluoro-6-methylphenyl)boronic acid(WX900172);(2-Fluoro-6-methylphenyl)boronic acid - [F88944]
CBNumber: CB42503756
Molecular Formula: C7H8BFO2
Formula Weight: 153.95
MOL File: 887471-69-4.mol

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2-Fluoro-6-methylphenylboronic acid Property

Boiling point:: 285.9±50.0 °C(Predicted)
Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 8.40±0.58(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F596510
Product name: 2-Fluoro-6-methylphenylboronicacid
Packaging: 100mg
Price: $110
Updated: 2021/12/16

TRC

Product number: F596510
Product name: 2-Fluoro-6-methylphenylboronicacid
Packaging: 500mg
Price: $470
Updated: 2021/12/16

TRC

Product number: F596510
Product name: 2-Fluoro-6-methylphenylboronicacid
Packaging: 1g
Price: $825
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 35812
Product name: (2-Fluoro-6-methylphenyl)boronicacid
Purity: 95+%
Packaging: 1g
Price: $880
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0006420
Product name: (2-FLUORO-6-METHYLPHENYL)BORONIC ACID
Purity: 95.00%
Packaging: 1G
Price: $975.45
Updated: 2021/12/16

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2-Fluoro-6-methylphenylboronic acid Chemical Properties,Usage,Production

Uses

2-Fluoro-6-methylphenylboronic acid is used in biochemical methods of study as a reagent for fluorinated boronic acid-appended pyridinium salts and 19F NMR Spectroscopy for diol sensing.

Synthesis

59907-13-0

887471-69-4

General procedure for the synthesis of (2-fluoro-6-methylphenyl)boronic acid from 2-bromo-1-fluoro-3-methylbenzene: 2-bromo-1-fluoro-3-methylbenzene (300 mg, 1.59 mmol) was dissolved in anhydrous ether (3 mL), and triisopropyl borate (6.2 mL, 26.7 mmol) was added. The reaction mixture was cooled to -78 °C under argon protection. A tert-butyl lithium solution (1.7 M in pentane, 2.2 mL, 3.74 mmol) was added slowly and dropwise. The reaction system was then warmed to -10 °C and stirred at this temperature for 30 min. Upon completion of the reaction, 5N hydrochloric acid (2 mL) was added and stirring was continued for 30 minutes at room temperature. The reaction mixture was extracted twice with diisopropyl ether and the organic layers were combined and alkalized with 2N sodium hydroxide solution. The aqueous phase was adjusted to pH 1 with hydrochloric acid and extracted twice with ether. The organic layers were combined, washed with saturated brine and dried over anhydrous sodium sulfate. The organic layer was concentrated under reduced pressure to give (2-fluoro-6-methylphenyl)boronic acid (117 mg, 43% yield) as a white solid. lRMS (m/z): 155 (M + 1)+.

References

[1] Patent: EP2738172, 2014, A1. Location in patent: Paragraph 0155
[2] Patent: WO2006/51410, 2006, A1. Location in patent: Page/Page column 43

2-Fluoro-6-methylphenylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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887471-69-4, 2-Fluoro-6-methylphenylboronic acidRelated Search:

2-Fluoro-6-methylphenylboronic acid

(2-fluoro-6-methylphenyl)boronic acid(WX900172)

Boronic acid, B-(2-fluoro-6-methylphenyl)-

2-iodo-3-(methoxymethyl)pyridine

(2-Fluoro-6-methylphenyl)boronic acid 97%

(2-Fluoro-6-methylphenyl)boronic acid - [F88944]

887471-69-4