3-Bromo-5-fluoro-4-pyridinecarboxylic acid
- Product Name
- 3-Bromo-5-fluoro-4-pyridinecarboxylic acid
- CAS No.
- 955372-86-8
- Chemical Name
- 3-Bromo-5-fluoro-4-pyridinecarboxylic acid
- Synonyms
- 3-BroMo-5-fluoroisonicotinic acid;3-Bromo-5-fluoro-4-pyridinecarboxylic acid;4-Pyridinecarboxylic acid, 3-broMo-5-fluoro-
- CBNumber
- CB42503963
- Molecular Formula
- C6H3BrFNO2
- Formula Weight
- 220
- MOL File
- 955372-86-8.mol
3-Bromo-5-fluoro-4-pyridinecarboxylic acid Property
- Boiling point:
- 367.4±42.0 °C(Predicted)
- Density
- 1.903±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.09±0.10(Predicted)
- Appearance
- Light yellow to brown Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B961690
- Product name
- 3-Bromo-5-fluoroisonicotinicAcid
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FB105603
- Product name
- 3-bromo-5-fluoropyridine-4-carboxylic Acid
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- PC520692
- Product name
- 3-Bromo-5-fluoro-pyridine-4-carboxylicacid
- Packaging
- 1g
- Price
- $151
- Updated
- 2021/12/16
- Product number
- FB105603
- Product name
- 3-bromo-5-fluoropyridine-4-carboxylic Acid
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FB105603
- Product name
- 3-bromo-5-fluoropyridine-4-carboxylic Acid
- Packaging
- 1g
- Price
- $300
- Updated
- 2021/12/16
3-Bromo-5-fluoro-4-pyridinecarboxylic acid Chemical Properties,Usage,Production
Synthesis
124-38-9
955372-86-8
General procedure for the synthesis of 3-bromo-5-fluoroisonicotinic acid from carbon dioxide: Intermediate 6: 3-bromo-5-fluoroisonicotinic acid; n-butyllithium (12.5 mL, 2.5 M solution of THF, 31.3 mmol) was slowly added to a solution of diisopropylamine (4.4 mL, 31.3 mmol) in THF (200 mL) at 0 °C and stirred for 15 min, then cooled to -78 °C. 3-Bromo-5-fluoropyridine (5.0 g, 28.4 mmol) solid was added and the resulting solution was stirred at -78 °C for 10 min. A gaseous carbon dioxide bulb was passed through a cannula into the solution for 30 min and the resulting solution was stirred for 2 h. The solution was warmed from -78 °C to room temperature. The reaction solution was concentrated by rotary evaporation, diluted with 2 M NaOH and washed with EtOAc. The aqueous solution was acidified with 1M HCl and extracted with EtOAc. The organic extract was washed with brine, dried over MgSO4, filtered and concentrated to give the target product 3-bromo-5-fluoroisonicotinic acid (4.75 g, 76% yield) as a solid.
References
[1] Patent: WO2007/123936, 2007, A1. Location in patent: Page/Page column 32; 67-68
3-Bromo-5-fluoro-4-pyridinecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Bromo-5-fluoro-4-pyridinecarboxylic acid manufacturers
- Product
- 3-Bromo-5-fluoro-4-pyridinecarboxylic acid 955372-86-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-12-19