methyl 5-methylbenzo[d]oxazole-2-carboxylate
- Product Name
- methyl 5-methylbenzo[d]oxazole-2-carboxylate
- CAS No.
- 27383-91-1
- Chemical Name
- methyl 5-methylbenzo[d]oxazole-2-carboxylate
- Synonyms
- methyl 5-methylbenzo[d]oxazole-2-carboxylate;2-Benzoxazolecarboxylic acid, 5-methyl-, methyl ester
- CBNumber
- CB42506131
- Molecular Formula
- C10H9NO3
- Formula Weight
- 191.18
- MOL File
- 27383-91-1.mol
methyl 5-methylbenzo[d]oxazole-2-carboxylate Property
- storage temp.
- 2-8°C
N-Bromosuccinimide Price
- Product number
- 1178DJ
- Product name
- Methyl5-methylbenzo[d]oxazole-2-carboxylate
- Packaging
- 1g
- Price
- $320
- Updated
- 2021/12/16
- Product number
- A104085
- Product name
- Methyl5-methylbenzo[d]oxazole-2-carboxylate
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $39
- Updated
- 2021/12/16
- Product number
- A104085
- Product name
- Methyl5-methylbenzo[d]oxazole-2-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $57
- Updated
- 2021/12/16
- Product number
- A104085
- Product name
- Methyl5-methylbenzo[d]oxazole-2-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $141
- Updated
- 2021/12/16
- Product number
- CD11155127
- Product name
- Methyl5-methylbenzo[d]oxazole-2-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $244
- Updated
- 2021/12/16
methyl 5-methylbenzo[d]oxazole-2-carboxylate Chemical Properties,Usage,Production
Synthesis
10531-78-9
124-38-9
74-88-4
27383-91-1
Catalyst (9.9 mg, 0.025 mmol, 5 mol%), potassium tert-butoxide (0.0672 g, 0.6 mmol) and DMF (3.0 mL) were added to the reaction flask under argon protection. Subsequently, 5-methylbenzazole (66.58 mg, 0.5 mmol) was added and the reaction mixture was stirred at 80 °C for 18 h at atmospheric pressure. After completion of the reaction, the system was cooled to 65 °C, iodomethane (93 μL, 1.5 mmol) was added and stirring was continued for 1 h at the same temperature. At the end of the reaction, the reaction was quenched with ethyl acetate and purified by column chromatography (eluent: ethyl acetate/petroleum ether, 1:10, v/v) to afford the target product methyl 5-methylbenzo[D]oxazole-2-carboxylate in 88% yield.
References
[1] Green Chemistry, 2018, vol. 20, # 5, p. 989 - 996
[2] Patent: CN106565623, 2017, A. Location in patent: Paragraph 0040
[3] Organic Letters, 2010, vol. 12, # 15, p. 3567 - 3569
[4] Green Chemistry, 2013, vol. 15, # 3, p. 635 - 640
methyl 5-methylbenzo[d]oxazole-2-carboxylate Preparation Products And Raw materials
Raw materials
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