2-Pyridineacetic acid, 5-nitro-, methyl ester
- Product Name
- 2-Pyridineacetic acid, 5-nitro-, methyl ester
- CAS No.
- 292600-22-7
- Chemical Name
- 2-Pyridineacetic acid, 5-nitro-, methyl ester
- Synonyms
- Methyl 5-Nitropyridine-2-acetate;Methyl 5-nitro-2-pyridineacetate;methyl 2-(5-nitro-2-pyridyl)acetate;Methyl 2-(5-nitropyridin-2-yl)acetate;2-Pyridineacetic acid, 5-nitro-, methyl ester
- CBNumber
- CB42506191
- Molecular Formula
- C8H8N2O4
- Formula Weight
- 196.16
- MOL File
- 292600-22-7.mol
2-Pyridineacetic acid, 5-nitro-, methyl ester Property
- storage temp.
- Inert atmosphere,Room Temperature
- Appearance
- Brown to reddish brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M350753
- Product name
- Methyl2-(5-nitropyridin-2-yl)acetate
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- M350753
- Product name
- Methyl2-(5-nitropyridin-2-yl)acetate
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 2966AB
- Product name
- Methyl2-(5-nitropyridin-2-yl)acetate
- Packaging
- 1g
- Price
- $388
- Updated
- 2021/12/16
- Product number
- CHM0392888
- Product name
- METHYL-2-(5-NITROPYRIDIN-2-YL)ACETATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.05
- Updated
- 2021/12/16
- Product number
- 35876
- Product name
- Methyl2-(5-nitropyridin-2-yl)acetate
- Purity
- 95+%
- Packaging
- 1000mg
- Price
- $780
- Updated
- 2021/12/16
2-Pyridineacetic acid, 5-nitro-, methyl ester Chemical Properties,Usage,Production
Synthesis
4548-45-2
42726-73-8
292600-22-7
1. tert-Butyl malonate (2.64 g, 15.14 mmol) was dissolved in tetrahydrofuran (THF, 50 mL). Sodium hydride (0.605 g, 15.14 mmol) was added in batches at 0 °C, followed by stirring the reaction mixture for 15 min at room temperature. 2. 2-chloro-5-nitropyridine (2.01 g, 12.61 mmol) was dissolved in THF (10 mL), added to the above mixture, and stirring was continued for 4 hours at room temperature. 3. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution followed by three extractions with ethyl acetate (EtOAc). The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. 4. The resulting residue was dissolved in a solvent mixture of dichloromethane (DCM) and trifluoroacetic acid (TFA) (30 mL, 2:1, v/v/v) and stirred for 1.5 hours. 5. The reaction mixture was diluted with 1.5 M potassium phosphate solution and again extracted three times with EtOAc. The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. 6. The residue was dissolved in dichloromethane and purified by silica gel column chromatography (80 g silica gel, elution gradient: 30-100% EtOAc in hexane solution). 7. The eluate containing the target product was collected and concentrated to give Intermediate I-109A (1.06 g, 5.40 mmol, 42.8% yield) as a yellow oil. LC-MS analysis (Method H): MS (ESI) m/z: 197.0 [M + H]+. 1H NMR (400 MHz, CDCl3) δ: 9.41 (d, J = 2.6 Hz, 1H), 8.49 (dd, J = 8.6, 2.6 Hz, 1H), 7.56 (d, J = 8.6 Hz, 1H), 4.02 (s, 2H), 3.78 (s, 3H).
References
[1] Patent: WO2018/13774, 2018, A1. Location in patent: Page/Page column 246
2-Pyridineacetic acid, 5-nitro-, methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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