2-Amino-4-bromo-5-chloropyridine
- Product Name
- 2-Amino-4-bromo-5-chloropyridine
- CAS No.
- 1187449-01-9
- Chemical Name
- 2-Amino-4-bromo-5-chloropyridine
- Synonyms
- 4-BroMo-5-chloropyridin-2-aMine;2-Amino-4-bromo-5-chloropyridine;2-Pyridinamine, 4-bromo-5-chloro-;4-BroMo-5-chloro-pyridin-2-ylaMine
- CBNumber
- CB42507017
- Molecular Formula
- C5H4BrClN2
- Formula Weight
- 207.46
- MOL File
- 1187449-01-9.mol
2-Amino-4-bromo-5-chloropyridine Property
- Boiling point:
- 299.8±35.0 °C(Predicted)
- Density
- 1.834±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 3.63±0.24(Predicted)
- Appearance
- White to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B700743
- Product name
- 4-Bromo-5-chloropyridin-2-amine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-0030446
- Product name
- 2-Amino-4-bromo-5-chloropyridine
- Purity
- 95.78%
- Packaging
- 5g
- Price
- $285
- Updated
- 2021/12/16
- Product number
- Z8024
- Product name
- 4-Bromo-5-chloropyridin-2-amine
- Packaging
- 5g
- Price
- $500
- Updated
- 2021/12/16
- Product number
- CS-0030446
- Product name
- 2-Amino-4-bromo-5-chloropyridine
- Purity
- 95.78%
- Packaging
- 1g
- Price
- $71
- Updated
- 2021/12/16
- Product number
- CM244056
- Product name
- 4-Bromo-5-chloropyridin-2-amine
- Purity
- 95%
- Packaging
- 10g
- Price
- $514
- Updated
- 2021/12/16
2-Amino-4-bromo-5-chloropyridine Chemical Properties,Usage,Production
Synthesis
84249-14-9
1187449-01-9
General procedure for the synthesis of 4-bromo-5-chloro-2-aminopyridine from 2-amino-4-bromopyridine: [00252] Synthesis of 4-bromo-5-chloropyridin-2-amine: to a stirred solution of 4-bromopyridin-2-amine (30.0 g, 173 mmol) in DMF (350 mL) was slowly added 1-chloropyrrolidine-2,5-dione at -20 °C ( 24.3 g, 182 mmol). The reaction mixture was stirred continuously at room temperature for 24 hours. Upon completion of the reaction, the mixture was slowly poured into pre-cooled aqueous 1 M NaOH solution (300 mL). Extraction was carried out with ether (2 x 400 mL), the organic phases were combined and washed sequentially with water (3 x 200 mL), brine (200 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by recrystallization from dichloromethane to afford the target compound 27A as a red solid (22.0 g, 106 mmol, 61% yield).LC-MS analysis: the theoretical molecular weight of C5H4BrClN2 was 205.93, and the measured [M + H]+ was 206.9.
References
[1] Patent: WO2014/78609, 2014, A1. Location in patent: Paragraph 00252
[2] Patent: US9133163, 2015, B2. Location in patent: Page/Page column 89; 90
[3] Patent: WO2009/112473, 2009, A1. Location in patent: Page/Page column 68-69
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 8, p. 2552 - 2555
[5] Patent: US2016/376287, 2016, A1. Location in patent: Paragraph 0624
2-Amino-4-bromo-5-chloropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-4-bromo-5-chloropyridine manufacturers
- Product
- 2-Amino-4-bromo-5-chloropyridine 1187449-01-9
- Price
- US $1.00-4.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2025-09-04
- Product
- 2-Amino-4-bromo-5-chloropyridine 1187449-01-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-08-22