3-(TRIFLUOROMETHYL)BENZAMIDE
- Product Name
- 3-(TRIFLUOROMETHYL)BENZAMIDE
- CAS No.
- 1801-10-1
- Chemical Name
- 3-(TRIFLUOROMETHYL)BENZAMIDE
- Synonyms
- TIMTEC-BB SBB002332;m-Trifluoromethylbenzamide;à,à,à-trifluoro-m-toluamide;N-(trifluoromethyl)benzamide;3-(TRIFLUOROMETHYL)BENZAMIDE;N-(3-Trifluoromethyl)benzamide;Benzamide, 3-(trifluoromethyl)-;3-(Trifluoromethyl)benzamide98%;3-(Trifluoromethyl)benzamide 98%;3-
(TrifluoroMethyl) benzaMide - CBNumber
- CB4250753
- Molecular Formula
- C8H6F3NO
- Formula Weight
- 189.13
- MOL File
- 1801-10-1.mol
3-(TRIFLUOROMETHYL)BENZAMIDE Property
- Melting point:
- 124-127 °C (lit.)
- Boiling point:
- 241.3±40.0℃ (760 Torr)
- Density
- 1.335±0.06 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 99.7±27.3℃
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 15.31±0.50(Predicted)
- Appearance
- White to off-white Solid
- BRN
- 1955599
- CAS DataBase Reference
- 1801-10-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 548146
- Product name
- 3-(Trifluoromethyl)benzamide
- Purity
- 98%
- Packaging
- 5g
- Price
- $34.8
- Updated
- 2023/06/20
- Product number
- T797035
- Product name
- 3-(Trifluoromethyl)benzamide
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- T797035
- Product name
- 3-(Trifluoromethyl)benzamide
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- T797035
- Product name
- 3-(Trifluoromethyl)benzamide
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 005389
- Product name
- 3-(Trifluoromethyl)benzamide
- Purity
- 98%
- Packaging
- 100g
- Price
- $160
- Updated
- 2021/12/16
3-(TRIFLUOROMETHYL)BENZAMIDE Chemical Properties,Usage,Production
Chemical Properties
White to light yellow crystal powde
General Description
3-(Trifluoromethyl)benzamide can be prepared from 1-bromo-3-trifluoromethylbenzene via palladium-catalyzed aminocarbonylation with formamide. It forms the core moiety of N-[(substituted 1H-imidazol-1-yl)propyl]benzamides, with potential as antihypertensive agents.
Synthesis
368-77-4
1801-10-1
GENERAL STEPS: To a flame-dried, resealable 2-5 mL Pyrex reaction vessel were added the solid reactants: m-trifluoromethylbenzonitrile (1.0 mmol) and Cs2CO3 (1.5 mmol). The reaction vessel was sealed with a rubber septum and pyrrolidone (2 mL/mmol [0.5 M]) was injected through the septum. Subsequently, the rubber septum was replaced with a PTFE screw cap. The sealed reaction vessel was heated in an oil bath at 130°C for 2 hours. Upon completion of the reaction, the resulting suspension was cooled to room temperature, filtered through a diatomaceous earth pad and eluted with a solvent mixture of CH2Cl2/MeOH (7:3) to remove inorganic salts. Finally, the filtrate was concentrated and the residue was purified by silica gel column chromatography to afford the target product 3-(trifluoromethyl)benzamide.
References
[1] Tetrahedron Letters, 2012, vol. 53, # 23, p. 2860 - 2863
[2] Catalysis Science and Technology, 2015, vol. 5, # 5, p. 2865 - 2868
3-(TRIFLUOROMETHYL)BENZAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(TRIFLUOROMETHYL)BENZAMIDE manufacturers
- Product
- 3-(TRIFLUOROMETHYL)BENZAMIDE 1801-10-1
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-30