ChemicalBook > CAS DataBase List > MK 3207 hydrochloride

MK 3207 hydrochloride

Product Name: MK 3207 hydrochloride
CAS No.: 957116-20-0
Chemical Name: MK 3207 hydrochloride
Synonyms: CS-549;MK3207 HCl;MK-3207 HCl salt;MK 3207 hydrochloride;MK3207 MK-3207 hydrochloride HCL;MK3207 HYDROCHLORIDE;MK 3207 HYDROCHLORIDE;MK-3207;2-[(8R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]decan-9-yl]-N-[(3R)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,2'-indane]-5'-yl]acetamide;2-((R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)-N-((R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)acetamide hydrochloride;6,9-Diazaspiro[4.5]decane-9-acetamide, 8-(3,5-difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-, hydrochloride;(8R)-8-(3,5-Difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-6,9-diazaspiro[4.5]decane-9-acetamide hydrochloride
CBNumber: CB42509985
Molecular Formula: C31H30ClF2N5O3
Formula Weight: 594.06
MOL File: 957116-20-0.mol

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MK 3207 hydrochloride Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
color: Off-white to pink

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0351
Product name: MK-3207Hydrochloride
Purity: 99.06%
Packaging: 10mg
Price: $330
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000883
Product name: MK-3207 HYDROCHLORIDE
Purity: 95.00%
Packaging: 10MG
Price: $1006.58
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000883
Product name: MK-3207 HYDROCHLORIDE
Purity: 95.00%
Packaging: 50MG
Price: $1734.23
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000883
Product name: MK-3207 HYDROCHLORIDE
Purity: 95.00%
Packaging: 1G
Price: $8853.08
Updated: 2021/12/16

DC Chemicals

Product number: DC9397
Product name: MK-3207(Hydrochloride)
Purity: >98%
Packaging: 1g
Price: $2600
Updated: 2021/12/16

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MK 3207 hydrochloride Chemical Properties,Usage,Production

Uses

MK-3207 (Hydrochloride) is a potent and orally bioavailable CGRP receptor antagonist with IC50 of 0.12 nM and Ki of 0.024 nM, and is highly selective versus human AM1, AM2, CTR, and AMY3.

Biological Activity

MK-3207 HCl is a potent CGRP receptor antagonist with IC50 and K_i of 0.12 nM and 0.022 nM, respectively, with high selectivity for human AM1, AM2, CTR, and AMY3. Phase 2.

in vivo

MK-3207 is CNS-penetrant and therefore significantly engaging central receptors. After an oral dose of 10 mg/kg MK-3207, the CSF/plasma ratio is 2 to 3%^[1].

References

[1] Salvatore CA, et al. Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist. J Pharmacol Exp Ther. 2010 Apr;333(1):152-60. DOI:10.1124/jpet.109.163816

MK 3207 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from MK 3207 hydrochloride manufacturers

Career Henan Chemical Co

Product: MK-3207 HCl 957116-20-0
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1ton
Release date: 2020-01-10

957116-20-0, MK 3207 hydrochlorideRelated Search:

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MK3207 HYDROCHLORIDE;MK 3207 HYDROCHLORIDE;MK-3207

2-((R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)-N-((R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)acetamide hydrochloride

CS-549

(8R)-8-(3,5-Difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-6,9-diazaspiro[4.5]decane-9-acetamide hydrochloride

MK 3207 hydrochloride

MK-3207 HCl salt

MK3207 HCl

6,9-Diazaspiro[4.5]decane-9-acetamide, 8-(3,5-difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-, hydrochloride

(8R)-8-(3,5-Difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-6,9-diazaspiro[4.5]decane-9-acetamide hydrochloride USP/EP/BP

MK3207 MK-3207 hydrochloride HCL

2-[(8R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]decan-9-yl]-N-[(3R)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,2'-indane]-5'-yl]acetamide

957116-20-0

C31H29F2N5O3HCl

C31H29F2N5O3ClH

Inhibitors