Prucalopride Succinate

Product Name: Prucalopride Succinate
CAS No.: 179474-85-2
Chemical Name: Prucalopride Succinate
Synonyms: R-108512;RESOLOR; R-108512;Resolor Succinate;PRUCALOPRIDE SUCCITE;Prucalopride Impurity;Prucalopride Succinat;Priucapride succinate;Prucalopride Succinate;Prucalopride Succinate WS;PRUCALOPRIDE INTERMEDIATES
CBNumber: CB42510031
Molecular Formula: C22H32ClN3O7
Formula Weight: 485.96
MOL File: 179474-85-2.mol

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Prucalopride Succinate Property

Melting point:: >196°C (dec.)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Pale Brown
InChI: InChI=1S/C18H26ClN3O3.C4H6O4/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14;5-3(6)1-2-4(7)8/h11-12H,2-10,20H2,1H3,(H,21,23);1-2H2,(H,5,6)(H,7,8)
InChIKey: QZRSNVSQLGRAID-UHFFFAOYSA-N
SMILES: C(O)(=O)CCC(O)=O.O1C2=C(C(NC3CCN(CCCOC)CC3)=O)C=C(Cl)C(N)=C2CC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: P838950
Product name: PrucaloprideSuccinate
Packaging: 250mg
Price: $275
Updated: 2021/12/16

ChemScene

Product number: CS-3907
Product name: Prucalopridesuccinate
Purity: 99.83%
Packaging: 200mg
Price: $270
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 48434
Product name: PrucaloprideSuccinate
Packaging: 50mg
Price: $675
Updated: 2021/12/16

ChemScene

Product number: CS-3907
Product name: Prucalopridesuccinate
Purity: 99.83%
Packaging: 50mg
Price: $96
Updated: 2021/12/16

AK Scientific

Product number: Y0234
Product name: Prucalopridesuccinate
Packaging: 100mg
Price: $147
Updated: 2021/12/16

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Prucalopride Succinate Chemical Properties,Usage,Production

Chemical Properties

Butanedioic acid 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide is Off-White to Pale Brown Solid

Uses

Butanedioic acid 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide is a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe.

Uses

Prucalopride is a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe.

Clinical Use

Prucalopride succinate, a first-in-class dihydrobenzofurancarboxamide, is a selective serotonin (5- HT4) receptor agonist. The drug, marketed under the brand name Resolor®, possesses enterokinetic activity and was developed by the Belgian-based pharmaceutical firm Movetis. Prucalopride alters colonic motility patterns via serotonin 5-HT4 receptor stimulation, triggering the central propulsive force for defecation.

Synthesis

The preparation of prucalopride succinate begins with the commercially available salicylic aniline 124. Acidic esterification, acetylation of the aniline nitrogen atom, and ambient-temperature chlorination via sulfuryl chloride (SO2Cl2) converted aminophenol 124 to acetamidoester 125 in 83% yield over the course of three steps. An unique set of conditions involving sodium tosylchloramide (chloramine T) trihydrate and sodium iodide were then employed to convert 125 to o-phenolic iodide 126, which then underwent sequential Sonogashira/cyclization reaction utilizing TMS-acetylene with tetramethylguanidine (TMG) in the presence of silica gel to furnish the benzofuran progenitor of 127. Hydrogenation of this intermediate benzofuranyl Sonagashira product saturated the 2,3-benzofuranyl bond while leaving the chlorine atom intact, ultimately delivering dihydrobenzofuran 127 in excellent yield for the two step sequence. Base-induced saponification and acetamide removal gave rise to acid 128. This acid was activated as the corresponding mixed anhydride and treated with commercial piperidine 129 to construct prucalopride which was stirred at room temperature for 24 hours in ethanolic succinic acid to provide prucalopride succinate (XI). The yield for the formation of the salt was not provided.

Prucalopride Succinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Prucalopride Succinate Suppliers

Canada 1 China 208 India 20 United Kingdom 2 United States 12 Global 243

Shanghai Famo Bio-chemical Technology Company Ltd.

Tel: +862136680027 15800370750
Email: sales@famobiotech.com
Country: China
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Hefei TianRui Pharmaceutical Chemistry Co., Ltd.

Tel: 0551-68933033 13956024211
Fax: 0551-68935833
Email: trchem@163.com
Country: China
ProdList: 80
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J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
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Country: China
ProdList: 96815
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ZHIWE CHEMTECH CO LTD

Tel: 021-20221225 13917446399
Fax: QQ:115820162
Email: sales@zhiwe.net
Country: China
ProdList: 588
Advantage: 61

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5700
Advantage: 66

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 4550
Advantage: 62

Shanghai Hope Chem Co., Ltd.，

Tel: +21-18501659228 18501659228
Fax: sales@hope-chem.com
Email: info@hope-chem.com
Country: China
ProdList: 429
Advantage: 55

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4941
Advantage: 60

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View Lastest Price from Prucalopride Succinate manufacturers

Hangzhou ICH Biofarm Co., Ltd

Product: Prucalopride Succinate 179474-85-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 500kg
Release date: 2023-10-23

Zhuozhou Wenxi import and Export Co., Ltd

Product: Prucalopride succinate 179474-85-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Prucalopride succinate 179474-85-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

179474-85-2, Prucalopride SuccinateRelated Search:

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Butanedioic acid 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide

Prucalopride Succinate

Prucalopride Succinate API

PRUCALOPRIDE INTERMEDIATES

Prucalopride Succinat

Prucalopride Succinate WS

Butanedioic acid, compd. with 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide (1:1)

Prucalopride Impurity

R-108512

RESOLOR; R-108512

7-cyclopenta[b]pyrancarboxamide

4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide,butanedioic acid

4-amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide succinate

4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide Butanedioic Acid

Prucalopride succinate, 98.5%, a selective high affinity 5-HT4 receptor agonist

Resolor Succinate

Prucalopride Succinate USP/EP/BP

Prucalopride Succinate (R-108512, R-93877)

Butanedioic acid 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methox...

Prucalopride Succinate 13CD3Q: What is Prucalopride Succinate 13CD3 Q: What is the CAS Number of Prucalopride Succinate 13CD3

TIANFU-CHEM - Prucalopride Succinate

4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide,butanedioicaci

PRUCALOPRIDE SUCCITE

Prucalopride Succinate 4-amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3 -dihydrobenzofuran-7-carboxamide succinate

Priucapride succinate

179474-85-2

C22H32N3O7Cl

C18H26ClN3O3C4H6O4

Inhibitors