6,8-Dibromo-imidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester
- Product Name
- 6,8-Dibromo-imidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester
- CAS No.
- 87597-21-5
- Chemical Name
- 6,8-Dibromo-imidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester
- Synonyms
- Ethyl 6,8-dibromoimidazo[1,2-a]pyrazine-2-carboxylate;6,8-Dibromoimidazo[1,2-a]pyrazine-ethyl-2-carboxylate;6,8-Dibromo-imidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester;Imidazo[1,2-a]pyrazine-2-carboxylic acid, 6,8-dibromo-, ethyl ester
- CBNumber
- CB42510248
- Molecular Formula
- C9H7Br2N3O2
- Formula Weight
- 348.98
- MOL File
- 87597-21-5.mol
6,8-Dibromo-imidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester Property
- Density
- 2.06±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -3.87±0.30(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 094567
- Product name
- Ethyl 6,8-dibromoimidazo[1,2-a]pyrazine-2-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $341
- Updated
- 2021/12/16
- Product number
- 094567
- Product name
- Ethyl 6,8-dibromoimidazo[1,2-a]pyrazine-2-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $756
- Updated
- 2021/12/16
- Product number
- 3898AC
- Product name
- Ethyl6,8-dibromoimidazo[1,2-a]pyrazine-2-carboxylate
- Packaging
- 250mg
- Price
- $158
- Updated
- 2021/12/16
- Product number
- CC00-9674
- Product name
- 6,8-Dibromo-imidazo[1,2-a]pyrazine-2-carboxylicacidethylester
- Purity
- ＞97%
- Packaging
- 0.5g
- Price
- $175
- Updated
- 2021/12/16
- Product number
- CD11038080
- Product name
- Ethyl6,8-dibromoimidazo[1,2-a]pyrazine-2-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $238
- Updated
- 2021/12/16
6,8-Dibromo-imidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester Chemical Properties,Usage,Production
Synthesis
70-23-5
24241-18-7
87597-21-5
Step A: Preparation of ethyl 6,8-dibromoimidazo[1,2-a]pyrazine-2-carboxylate At room temperature, 2-amino-3,5-dibromopyrazine (20 g, 79 mmol) was dissolved in dimethyl carbonate (133 mL) and stirred until completely dissolved. Subsequently, ethyl 3-bromo-2-oxopropionate (17.14 g, 79 mmol) was added to the reaction system in one go. The reaction mixture was heated to 110 °C with continuous stirring for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and stirring was continued overnight. Water and dichloromethane (DCM) were added to the reaction mixture, the aqueous phase was separated and extracted with DCM. The organic phases were combined, washed with water, dried over anhydrous sodium sulfate (Na2SO4), filtered and the solvent evaporated. Purification by fast column chromatography afforded 13.95 g (50.6% yield) of ethyl 6,8-dibromoimidazo[1,2-a]pyrazine-2-carboxylate, the target compound. The product was characterized by 1H-NMR (300 MHz, CDCl3): δ= 8.30 (s, 1H), 8.27 (s, 1H), 4.48 (q, 2H), 1.43 (t, 3H) ppm.
References
[1] Patent: WO2012/80232, 2012, A1. Location in patent: Page/Page column 36-37
[2] Patent: WO2012/80228, 2012, A1. Location in patent: Page/Page column 42-43
[3] Patent: WO2012/80234, 2012, A1. Location in patent: Page/Page column 45
[4] Patent: WO2012/80236, 2012, A1. Location in patent: Page/Page column 64
[5] Patent: US2013/281460, 2013, A1. Location in patent: Paragraph 0270-0271
6,8-Dibromo-imidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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