ChemicalBook > CAS DataBase List > 4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide

4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide

Product Name
4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide
CAS No.
870070-55-6
Chemical Name
4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide
Synonyms
CS-297;SYN-115;RO4494351;Tozadenant;RO 4494351;RO-4494351;SYN-115 (Tozadenant);Tozadenant (SYN-115);SYN-115;SYN115;SYN 115;4-Hydroxy-N-[4-methoxy-7-...
CBNumber
CB42514635
Molecular Formula
C19H26N4O4S
Formula Weight
406.5
MOL File
870070-55-6.mol
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4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide Property

Density 
1.374
storage temp. 
Store at -20°C
solubility 
insoluble in EtOH; insoluble in H2O; ≥20.35 mg/mL in DMSO
form 
Powder
pka
14.95±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28452
Product name
Tozadenant
Packaging
10mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
28452
Product name
Tozadenant
Packaging
25mg
Price
$113
Updated
2024/03/01
Cayman Chemical
Product number
28452
Product name
Tozadenant
Packaging
50mg
Price
$194
Updated
2024/03/01
Cayman Chemical
Product number
28452
Product name
Tozadenant
Packaging
100mg
Price
$330
Updated
2024/03/01
ApexBio Technology
Product number
A3885
Product name
Tozadenant
Packaging
50mg
Price
$585
Updated
2021/12/16
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4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide Chemical Properties,Usage,Production

Description

Tozadenant is an adenosine A2A receptor antagonist (Kis = 11.5 and 6 nM for the human and rhesus monkey receptors, respectively). It increases the distance traveled and reduces contralateral asymmetry in the open field test in a rat model of Parkinson''s disease induced by 6-OHDA when administered at a dose of 30 mg/kg. Tozadenant (150 mg/kg) reverses locomotor deficits and restores novel object-stimulated locomotion in a marmoset model of MPTP-induced Parkinson''s disease.

Definition

ChEBI: Tozadenant is a member of benzothiazoles.

target

adenosine A2A receptor

References

hauser ra, olanow cw, kieburtz kd et al. tozadenant (syn115) in patients with parkinson's disease who have motor fluctuations on levodopa: a phase 2b, double-blind, randomised trial. lancet neurol. 2014 aug;13(8):767-76.

4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide Suppliers

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View Lastest Price from 4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Tozadenant 870070-55-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Tozadenant 870070-55-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

870070-55-6, 4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamideRelated Search:


  • 4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide
  • SYN-115
  • CS-297
  • SYN-115;SYN115;SYN 115
  • 4-Hydroxy-N-[4-methoxy-7-...
  • Tozadenant
  • 4-hydroxy-N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)-4-methylpiperidine-1-carboxamide
  • Tozadenant (SYN-115)
  • SYN-115 (Tozadenant)
  • 1-Piperidinecarboxamide, 4-hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-
  • 4-Methoxy-7-morpholino-2-[(4-hydroxy-4-methylpiperidino)carbonylamino]benzothiazole
  • P1 receptor,SYN-115,Adenosine Receptor,SYN 115,Tozadenant,Inhibitor,inhibit
  • RO 4494351
  • RO4494351
  • RO-4494351
  • 870070-55-6