2-bromo-1-iodo-4-methoxybenzene
- Product Name
- 2-bromo-1-iodo-4-methoxybenzene
- CAS No.
- 466639-53-2
- Chemical Name
- 2-bromo-1-iodo-4-methoxybenzene
- Synonyms
- 3-Bromo-4-iodoanisole;3-Bromo-4-iodoanisole97%;3-Bromo-4-iodoanisole 97%;2-bromo-1-iodo-4-methoxybenzene;Benzene, 2-bromo-1-iodo-4-methoxy-;2-Bromo-1-iodo-4-methoxybenzene, 3-Bromo-4-iodophenyl methyl ether
- CBNumber
- CB42514923
- Molecular Formula
- C7H6BrIO
- Formula Weight
- 312.93
- MOL File
- 466639-53-2.mol
2-bromo-1-iodo-4-methoxybenzene Property
- Boiling point:
- 284.9±25.0 °C(Predicted)
- Density
- 2.062±0.06 g/cm3(Predicted)
- refractive index
- 1.65
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- clear liquid
- color
- Colorless to Red to Green
Safety
- HazardClass
- IRRITANT
- HS Code
- 2909309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B5697
- Product name
- 3-Bromo-4-iodoanisole
- Packaging
- 1G
- Price
- $48
- Updated
- 2025/07/31
- Product number
- B5697
- Product name
- 3-Bromo-4-iodoanisole
- Packaging
- 5G
- Price
- $189
- Updated
- 2025/07/31
- Product number
- B693528
- Product name
- 2-Bromo-1-iodo-4-methoxybenzene
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- B693528
- Product name
- 2-Bromo-1-iodo-4-methoxybenzene
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 2607-S-01
- Product name
- 3-Bromo-4-iodoanisole
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
2-bromo-1-iodo-4-methoxybenzene Chemical Properties,Usage,Production
Uses
2-bromo-1-iodo-4-methoxybenzene is an ether organic compound used in organic synthesis.
Synthesis
2398-37-0
466639-53-2
General procedure for the synthesis of 2-bromo-1-iodo-4-methoxybenzene using 3-bromoanisole as starting material: 3-bromoanisole (10 g, 53.5 mmol), mercuric oxide (HgO, 8.8 g, 40.6 mmol) and acetic anhydride (Ac2O, 1 mL) were dissolved in dichloromethane (CH2Cl2, 100 mL) under stirring conditions, and refluxed for 30 minutes. Subsequently, iodine (I2, 17.6 g, 69.5 mmol) was added in six 12-hour intervals, and refluxing was continued for 12 hours after each addition. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and the filtrate was washed with saturated sodium thiosulfate (Na2S2O3) solution. The aqueous layer was extracted with dichloromethane (3 x 10 mL), the organic layers were combined and dried over anhydrous magnesium sulfate (MgSO4) and subsequently concentrated to dryness under reduced pressure. The crude product was purified by fast column chromatography (with cyclohexane as eluent) to afford the target compound 2-bromo-1-iodo-4-methoxybenzene as a colorless oil (94% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.68 (d, J = 8.8 Hz, 1H), 7.19 (d, J = 2.8 Hz, 1H), 6.59 (dd, J = 2.8 Hz, J = 8.8 Hz, 1H), 3.77 (s, 3H).
References
[1] European Journal of Medicinal Chemistry, 2010, vol. 45, # 9, p. 3617 - 3626
[2] Patent: WO2015/121785, 2015, A1. Location in patent: Page/Page column 39; 41
[3] Journal of the American Chemical Society, 2012, vol. 134, # 22, p. 9291 - 9295
[4] Chemical Communications, 2017, vol. 53, # 44, p. 5970 - 5973
[5] Organic and Biomolecular Chemistry, 2018, vol. 16, # 38, p. 7019 - 7028
2-bromo-1-iodo-4-methoxybenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-bromo-1-iodo-4-methoxybenzene manufacturers
- Product
- 2-bromo-1-iodo-4-methoxybenzene 466639-53-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-14
- Product
- 2-bromo-1-iodo-4-methoxybenzene 466639-53-2
- Price
- US $1.07-198.65/Kg
- Min. Order
- 1Kg
- Purity
- 99.0%
- Supply Ability
- 60 tons
- Release date
- 2023-06-27
- Product
- 2-bromo-1-iodo-4-methoxybenzene 466639-53-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11