6-tert-butylnicotinic acid
- Product Name
- 6-tert-butylnicotinic acid
- CAS No.
- 832715-99-8
- Chemical Name
- 6-tert-butylnicotinic acid
- Synonyms
- 6-tert-butylnicotinic acid;6-(tert-Butyl)-pyridin-3-carboxylic acid;6-(1,1-dimethylethyl)-3-Pyridinecarboxylic acid;3-Pyridinecarboxylic acid, 6-(1,1-diMethylethyl)-
- CBNumber
- CB42515001
- Molecular Formula
- C10H13NO2
- Formula Weight
- 179.22
- MOL File
- 832715-99-8.mol
6-tert-butylnicotinic acid Property
- storage temp.
- Inert atmosphere,Room Temperature
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B814160
- Product name
- 6-tert-butylnicotinicacid
- Packaging
- 500mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- B814160
- Product name
- 6-tert-butylnicotinicacid
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- OR930175
- Product name
- 6-tert-Butylnicotinicacid
- Purity
- 98%
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 112735
- Product name
- 6-(1,1-Dimethylethyl)-3-pyridinecarboxylic acid
- Packaging
- 5g
- Price
- $1179
- Updated
- 2021/12/16
- Product number
- 2849AC
- Product name
- 6-(tert-Butyl)nicotinicacid
- Packaging
- 10g
- Price
- $1345
- Updated
- 2021/12/16
6-tert-butylnicotinic acid Chemical Properties,Usage,Production
Synthesis
59-67-6
815-17-8
832715-99-8
Step 1: Preparation of 6-tert-butylnicotinic acid To a suspension of nicotinic acid (2.00 g, 16.2 mmol) in water (250 mL) was added concentrated sulfuric acid (1 mL, 18.8 mmol) and stirred under nitrogen protection until a clear solution was formed. Subsequently, neopentanoic acid (1.83 g, 17.9 mmol) was added and stirring was continued for 10 minutes at room temperature under nitrogen protection. Silver nitrate (125 mg, 0.74 mmol) and ammonium persulfate (295 mg, 1.3 mmol) were added sequentially, the flask was wrapped in aluminum foil to protect from light, and the reaction mixture was heated to 90 °C under nitrogen protection. After 2 hours of reaction, the reaction was cooled to room temperature and the aqueous phase mixture was concentrated under reduced pressure to give a colorless solid. The solid was ground with tetrahydrofuran and filtered, the solid residue was recrystallized with methanol and filtered again. The two filtrates were combined and concentrated under reduced pressure. The crude product was purified by reversed-phase chromatography using an 85 g C-18 column eluting with a gradient of 10% aqueous acetonitrile to 100% acetonitrile. The product-containing fraction was collected and concentrated under reduced pressure. The residue was lyophilized in water to give 6-tert-butylnicotinic acid as a colorless solid (139 mg, 4% yield). LC/MS: m/z calculated value C10H13NO2 ([M+H]+): 180.2. measured value: 180.1 (positive ion mode, electrospray ionization).
References
[1] Patent: WO2014/90715, 2014, A1. Location in patent: Page/Page column 45
6-tert-butylnicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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