8-bromoquinazoline-2,4(1H,3H)-dione

Product Name: 8-bromoquinazoline-2,4(1H,3H)-dione
CAS No.: 331646-99-2
Chemical Name: 8-bromoquinazoline-2,4(1H,3H)-dione
Synonyms: 8-Bromo-1H-quinazoline-2,4-dione;8-BROMO-2,4-DIHYDROXY QUINOZALINE;8-Bromo-2,4(1H,3H)-quinazolinedione;8-bromoquinazoline-2,4(1H,3H)-dione;2,4(1H,3H)-Quinazolinedione, 8-bromo-;8-bromo-1,2,3,4-tetrahydroquinazoline-2,4-dione
CBNumber: CB42515021
Molecular Formula: C8H5BrN2O2
Formula Weight: 241.04
MOL File: 331646-99-2.mol

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8-bromoquinazoline-2,4(1H,3H)-dione Property

Density: 1.752±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 10.29±0.20(Predicted)
Appearance: Off-white to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B688248
Product name: 8-Bromoquinazoline-2,4-diol
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B688248
Product name: 8-Bromoquinazoline-2,4-diol
Packaging: 25mg
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB42149
Product name: 8-Bromoquinazoline-2,4-diol
Packaging: 50mg
Price: $80
Updated: 2021/12/16

AK Scientific

Product number: W5486
Product name: 8-Bromoquinazoline-2,4-diol
Packaging: 100mg
Price: $108
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB42149
Product name: 8-Bromoquinazoline-2,4-diol
Packaging: 100mg
Price: $125
Updated: 2021/12/16

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8-bromoquinazoline-2,4(1H,3H)-dione Chemical Properties,Usage,Production

Synthesis

20776-51-6

57-13-6

331646-99-2

The general procedure for the synthesis of 8-bromoquinazoline-2,4(1H)-dione from 2-amino-3-bromobenzoic acid (10.8 g, 50 mmol, 1 eq.) and urea (15 g, 250 mmol, 5 eq.) was carried out as follows: a mixture of the above two raw materials was stirred and reacted for 3 hr at 200 °C. After completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice water. The resulting solid product was collected by filtration and subsequently washed three times with deionized water to remove impurities. Finally, the product was dried under vacuum to afford 8-bromoquinazoline-2,4(1H)-dione as a yellow solid (12.1 g, about 100% yield).

References

[1] Patent: WO2015/27222, 2015, A2. Location in patent: Paragraph 0213
[2] Patent: WO2016/133935, 2016, A1. Location in patent: Paragraph 0286
[3] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 9, p. 941 - 946

8-bromoquinazoline-2,4(1H,3H)-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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8-bromoquinazoline-2,4(1H,3H)-dione Suppliers

China 69 India 1 United Kingdom 2 United States 6 Global 78

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