ChemicalBook > CAS DataBase List > JNJ-40411813

JNJ-40411813

Product Name: JNJ-40411813
CAS No.: 1127498-03-6
Chemical Name: JNJ-40411813
Synonyms: CS-1035;ADX 71149;JNJ-40411813;JNJ 40411813;JNJ-40411813;JNJ-40411813, 10 mM in DMSO;1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl)pyridin-2-one;1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-2(1H)-Pyridinone;1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl)pyridin-2(1H)-one;2(1H)-Pyridinone, 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-;1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl)-1,2-dihydropyridin-2-one
CBNumber: CB42516013
Molecular Formula: C20H25ClN2O
Formula Weight: 344.88
MOL File: 1127498-03-6.mol

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JNJ-40411813 Property

Boiling point:: 463.5±45.0 °C(Predicted)
Density: 1.18±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:25.0(Max Conc. mg/mL);72.49(Max Conc. mM)
form: Solid
pka: 1.06±0.40(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-3357
Product name: JNJ-40411813
Purity: 98.97%
Packaging: 5mg
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-3357
Product name: JNJ-40411813
Purity: 98.97%
Packaging: 10mg
Price: $480
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb180849
Product name: JNJ40411813
Purity: >98%
Packaging: 100mg
Price: $1133.9
Updated: 2021/12/16

ChemScene

Product number: CS-3357
Product name: JNJ-40411813
Purity: 98.97%
Packaging: 100mg
Price: $2000
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb180849
Product name: JNJ40411813
Purity: >98%
Packaging: 250mg
Price: $2245.7
Updated: 2021/12/16

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JNJ-40411813 Chemical Properties,Usage,Production

Uses

ADX 71149 is drug candidate; used in preparation of Bipyridinones as positive allosteric modulators of mGluR2 for treating neurological and psychiatric disorders.Also, use as a treatment for ADHD.

in vivo

JNJ-40411813 (ADX-71149) (5-20 mg/kg; p.o.; 6 times in 24 h) clearly potentiated glutamate response in brain regions, more specifically in the cortical regions, striatum, and the hippocampus, coaddition of Glutamate (HY-N0455B)^[2].

Pharmacokinetic Analysis in SD rat^[2]

Route	Dose (mg/kg)	AUC_{INF_obs} (ng·h/mL)	t_1/2 (h)	T_max (h)	C_max (ng/mL)	Cl_obs (L·h/kg)	V_{ss_obs} (L/kg)
i.v.	2.5	1833±90	/	/	/	1.4±0.1	2.31.4±0.10.2
p.o.	10	2250±417	2.31±0.5	7	938	/	/

Animal Model:	Male Wistar Rats (150 mg)^[2]
Dosage:	5 mg/kg, 20 mg/kg
Administration:	Oral Gavage (p.o.)
Result:	Showed increasing in basal binding with an EC₅₀ of 48 μM and a Combined with 10 μM glutamate, [³⁵S]GTPγS binding with an EC₅₀ of 7.3 μM and a maximal effect of 380%.

IC 50

mGlu2 Receptor: 147 nM (EC₅₀)

JNJ-40411813 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from JNJ-40411813 manufacturers

Career Henan Chemical Co

Product: JNJ-40411813 1127498-03-6
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2020-01-08

1127498-03-6, JNJ-40411813Related Search:

JNJ-38431055 JNJ-42847922 JNJ-64619178

1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl)pyridin-2(1H)-one

1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-2(1H)-Pyridinone

JNJ-40411813

CS-1035

JNJ 40411813;JNJ-40411813

ADX 71149

2(1H)-Pyridinone, 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-

1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl)pyridin-2-one

ADX71149,JNJ-40411813,ADX 71149,JNJ40411813,mGluR,Inhibitor,JNJ 40411813,Metabotropic glutamate receptors,inhibit

1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl)-1,2-dihydropyridin-2-one

JNJ-40411813, 10 mM in DMSO

1127498-03-6