ChemicalBook > CAS DataBase List > (2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide

(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide

Product Name: (2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide
CAS No.: 300353-13-3
Chemical Name: (2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide
Synonyms: Ro 28-1675;Ro 0281675;RO281675,RO 28 1675;RO 028-1675;RO 0281675;RO 28-1675 (Ro 0281675);RO 28-1675 - RO 28-0450, (R)-;(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide;BenzeneacetaMide, α-(cyclopentylMethyl)-4-(Methylsulfonyl)-N-2-thiazolyl-, (αR)-
CBNumber: CB42516200
Molecular Formula: C18H22N2O3S2
Formula Weight: 378.51
MOL File: 300353-13-3.mol

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(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Property

Density: 1.306
storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (132.10 mM; Need ultrasonic)
form: Powder
pka: 8.65±0.50(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.09665
Product name: Glucokinase Activator III, Ro-28-1675
Packaging: 10mg
Price: $245
Updated: 2025/07/31

ChemScene

Product number: CS-2016
Product name: RO-28-1675
Purity: 99.95%
Packaging: 5mg
Price: $258
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0004737
Product name: (R)-3-CYCLOPENTYL-2-(4-METHANESULFONYL-PHENYL)-N-THIAZOL-2-YL-PROPIONAMIDE
Purity: 95.00%
Packaging: 2MG
Price: $262
Updated: 2021/12/16

ChemScene

Product number: CS-2016
Product name: RO-28-1675
Purity: 99.95%
Packaging: 10mg
Price: $444
Updated: 2021/12/16

Axon Medchem

Product number: Axon1356
Product name: RO28-1675-RO28-0450,(R)-
Purity: 99%
Packaging: 2mg
Price: $115.5
Updated: 2021/12/16

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(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Chemical Properties,Usage,Production

Definition

ChEBI: (2R)-3-cyclopentyl-2-(4-methylsulfonylphenyl)-N-(2-thiazolyl)propanamide is a member of acetamides.

Biological Activity

RO-28-1675 is a potent allosteric activator of glucokinase with EC50 of 54 nM. It can be used in type 2 diabetes research.

in vitro

RO-28-1675 can reverse the inhibitory action of the human glucokinase regulatory protein (GKRP).

in vivo

RO-28-1675 (50 mg/kg; po) reduces blood glucose levels in wild-type C57BL/6J mice.
RO-28-1675 (10 mg/kg; po) displays lower clearance and higher oral bioavailability.

Animal Model:	10 weeks old male C57BL/6J mice
Dosage:	50 mg/kg
Administration:	Oral administration
Result:	Reduced blood glucose levels.

Animal Model:	C57BL/6J mice
Dosage:	10 mg/kg
Administration:	Oral administr ation
Result:	AUC _0-inf (5150 ng? h/mL), C _max (1140 μg/mL) , T _max (3.3 hours ), F _po (92.8%) with 10 mg/kg orally administered.

target

EC50: 54 nM (glucokinase)

(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Suppliers

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300353-13-3, (2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamideRelated Search:

(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide

Ro 0281675

BenzeneacetaMide, α-(cyclopentylMethyl)-4-(Methylsulfonyl)-N-2-thiazolyl-, (αR)-

Ro 28-1675

RO 028-1675;RO 0281675

RO 28-1675 - RO 28-0450, (R)-

RO281675,RO 28 1675

RO 28-1675 (Ro 0281675)

300353-13-3

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