ChemicalBook > CAS DataBase List > (2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide

(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide

Product Name
(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide
CAS No.
300353-13-3
Chemical Name
(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide
Synonyms
Ro 28-1675;Ro 0281675;RO281675,RO 28 1675;RO 028-1675;RO 0281675;RO 28-1675 (Ro 0281675);RO 28-1675 - RO 28-0450, (R)-;(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide;BenzeneacetaMide, α-(cyclopentylMethyl)-4-(Methylsulfonyl)-N-2-thiazolyl-, (αR)-
CBNumber
CB42516200
Molecular Formula
C18H22N2O3S2
Formula Weight
378.51
MOL File
300353-13-3.mol
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(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Property

Density 
1.306
storage temp. 
Store at -20°C
solubility 
DMSO : 50 mg/mL (132.10 mM; Need ultrasonic)
form 
Powder
pka
8.65±0.50(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Axon Medchem
Product number
Axon1356
Product name
RO28-1675-RO28-0450,(R)-
Purity
99%
Packaging
2mg
Price
$115.5
Updated
2021/12/16
Axon Medchem
Product number
Axon1356
Product name
RO28-1675-RO28-0450,(R)-
Purity
99%
Packaging
5mg
Price
$159.5
Updated
2021/12/16
ChemScene
Product number
CS-2016
Product name
RO-28-1675
Purity
99.95%
Packaging
5mg
Price
$258
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0004737
Product name
(R)-3-CYCLOPENTYL-2-(4-METHANESULFONYL-PHENYL)-N-THIAZOL-2-YL-PROPIONAMIDE
Purity
95.00%
Packaging
2MG
Price
$262
Updated
2021/12/16
ChemScene
Product number
CS-2016
Product name
RO-28-1675
Purity
99.95%
Packaging
10mg
Price
$444
Updated
2021/12/16
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(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Chemical Properties,Usage,Production

Definition

ChEBI: (2R)-3-cyclopentyl-2-(4-methylsulfonylphenyl)-N-(2-thiazolyl)propanamide is a member of acetamides.

Biological Activity

RO-28-1675 is a potent allosteric activator of glucokinase with EC50 of 54 nM. It can be used in type 2 diabetes research.

in vitro

RO-28-1675 can reverse the inhibitory action of the human glucokinase regulatory protein (GKRP).

in vivo

RO-28-1675 (50 mg/kg; po) reduces blood glucose levels in wild-type C57BL/6J mice.
RO-28-1675 (10 mg/kg; po) displays lower clearance and higher oral bioavailability.

Animal Model: 10 weeks old male C57BL/6J mice
Dosage: 50 mg/kg
Administration: Oral administration
Result: Reduced blood glucose levels.
Animal Model: C57BL/6J mice
Dosage: 10 mg/kg
Administration: Oral administr ation
Result: AUC 0-inf (5150 ng? h/mL), C max (1140 μg/mL) , T max (3.3 hours ), F po (92.8%) with 10 mg/kg orally administered.

target

EC50: 54 nM (glucokinase)

(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Suppliers

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300353-13-3, (2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamideRelated Search:


  • (2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide
  • Ro 0281675
  • BenzeneacetaMide, α-(cyclopentylMethyl)-4-(Methylsulfonyl)-N-2-thiazolyl-, (αR)-
  • Ro 28-1675
  • RO 028-1675;RO 0281675
  • RO 28-1675 - RO 28-0450, (R)-
  • RO281675,RO 28 1675
  • RO 28-1675 (Ro 0281675)
  • 300353-13-3