ChemicalBook > CAS DataBase List > 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate

1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate

Product Name
1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
CAS No.
1216744-19-2
Chemical Name
1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
Synonyms
SK4112;SR6452;GSK 4112;GSK4112,SR6452;SR6452; SR-6452; SR 6452;tert-butyl N-(4-chlorobenzyl)-N-((5-nitrothiophen-2-yl)methyl)glycinate;tert-Butyl2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate;1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate;Glycine, N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]-, 1,1-dimethylethyl ester;SR-6452,hepatic damage,HepG2,Apoptosis,mice,Inhibitor,gluconeogenesis,bmal1,HDAC,hepatic gene,probe,Jo2,inhibit,Fas,GSK-4112,SR 6452,GSK4112,transcription,GSK 4112
CBNumber
CB42518693
Molecular Formula
C18H21ClN2O4S
Formula Weight
396.89
MOL File
1216744-19-2.mol
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1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate Property

Melting point:
95 - 96°C
Boiling point:
486.7±45.0 °C(Predicted)
Density 
1.296±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly, Heated)
form 
powder
pka
3.87±0.50(Predicted)
color 
off-white to tan
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Safety

Hazard Codes 
Xi
Risk Statements 
41-43
Safety Statements 
26-36/37/39
WGK Germany 
1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G0673
Product name
GSK4112
Purity
≥98% (HPLC)
Packaging
5MG
Price
$174
Updated
2023/06/20
Sigma-Aldrich
Product number
G0673
Product name
GSK4112
Purity
≥98% (HPLC)
Packaging
25MG
Price
$557
Updated
2023/06/20
Cayman Chemical
Product number
11931
Product name
GSK4112
Purity
≥98%
Packaging
5mg
Price
$65
Updated
2024/03/01
Cayman Chemical
Product number
11931
Product name
GSK4112
Purity
≥98%
Packaging
10mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
11931
Product name
GSK4112
Purity
≥98%
Packaging
25mg
Price
$286
Updated
2024/03/01
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1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate Chemical Properties,Usage,Production

Uses

GSK 4112 is a synthetic ligand for REV-ERBα, a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. GSK 4112 mimics the action of heme acting as agonist and suppresses the expression of REV-ERBα target genes involved in gluconeogenesis.

Biochem/physiol Actions

GSK4112 is a rev-erbα, (orphan nuclear receptor NR1D1) agonist, the first agent able to reset the circadian clock in a phase-dependent manner. Rev-erbα impacts the precision of the circadian clock by repressing target gene activities with the help of a nuclear receptor co-repressor complex (NCoR) and HDAC3. GSK4112 competes with heme (rev-erb′s natural ligand) and enhances co-repressor complex recruitment and thus, repression of transcription. suggests that pharmacological modulation through Rev-erb may provide new routes to treat metabolic diseases, especially disorders of adipogenesis regulated by rev-erba.

storage

Store at +4°C

1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate Preparation Products And Raw materials

Raw materials

Preparation Products

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1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate Suppliers

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View Lastest Price from 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate manufacturers

Career Henan Chemical Co
Product
1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate 1216744-19-2
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-25

1216744-19-2, 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinateRelated Search:


  • 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
  • GSK 4112
  • SR6452
  • GSK4112,SR6452
  • tert-Butyl2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate
  • SR6452; SR-6452; SR 6452
  • tert-butyl N-(4-chlorobenzyl)-N-((5-nitrothiophen-2-yl)methyl)glycinate
  • SK4112
  • Glycine, N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]-, 1,1-dimethylethyl ester
  • SR-6452,hepatic damage,HepG2,Apoptosis,mice,Inhibitor,gluconeogenesis,bmal1,HDAC,hepatic gene,probe,Jo2,inhibit,Fas,GSK-4112,SR 6452,GSK4112,transcription,GSK 4112
  • 1216744-19-2
  • Chelating Agents & Ligands, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds