Pep2m, myristoylated
- Product Name
- Pep2m, myristoylated
- CAS No.
- 1423381-07-0
- Chemical Name
- Pep2m, myristoylated
- Synonyms
- Pep2m, myristoylated
- CBNumber
- CB42518729
- Molecular Formula
- C63H118N18O14S
- Formula Weight
- 1383.81
- MOL File
- 1423381-07-0.mol
Pep2m, myristoylated Property
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- pka
- 3.25±0.10(Predicted)
- Water Solubility
- Soluble to 1 mg/ml in sterile water
N-Bromosuccinimide Price
- Product number
- 256211
- Product name
- Pep2m, myristoylated
- Packaging
- 1mg
- Price
- $466
- Updated
- 2021/12/16
- Product number
- B5479
- Product name
- Pep2m,myristoylated
- Packaging
- 1mg
- Price
- $235
- Updated
- 2021/12/16
Pep2m, myristoylated Chemical Properties,Usage,Production
Uses
Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m, myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC)[1][2].
in vivo
Pep2m, myristoylated (10 μg/20 μL) results in an increase in paw withdrawal thresholds (PWTs) on nociceptive responses in the formalin test[2].
| Animal Model: | Female and male Long-Evans hooded rats (8 weeks)[2] |
| Dosage: | 10 μg (in 20 μL) |
| Administration: | Intrathecal injection |
| Result: | Resulted in an increase in PWTs, in both male and female rats at various time points tested. |
References
[1] Yudong Yao, et al. PKMζ Maintains Late Long-Term Potentiation by N-Ethylmaleimide-Sensitive Factor/GluR2-Dependent Trafficking of Postsynaptic AMPA Receptors. J Neurosci. 2008 Jul 30; 28(31): 7820-7827. DOI:10.1523/JNEUROSCI.0223-08.2008
[2] Nicole C George, et al. Sex differences in the contributions of spinal atypical PKCs and downstream targets to the maintenance of nociceptive sensitization. Mol Pain. 2019; 15: 1744806919840582. DOI:10.1177/1744806919840582
Pep2m, myristoylated Preparation Products And Raw materials
Raw materials
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