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1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine

Product Name
1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine
CAS No.
1024448-59-6
Chemical Name
1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine
Synonyms
RN 1747;RN-1747 >=98% (HPLC);RN-1747, 10 mM in DMSO;1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine;1-Benzyl-4-(4-Chloro-2-Nitrobenzenesulfonyl)Piperazine;1-benzyl-4-((4-chloro-2-nitrophenyl)sulfonyl)piperazine;1-[(4-Chloro-2-nitrophenyl)sulfonyl]-4-(phenylmethyl)-piperazine;1-(4-Chloro-2-nitrophenyl)sulphonyl-4-benzylpiperazine (RN-1747);Piperazine, 1-[(4-chloro-2-nitrophenyl)sulfonyl]-4-(phenylmethyl)-;TRP Channel,RN-1747,Inhibitor,RN 1747,Transient receptor potential channels,RN1747,inhibit
CBNumber
CB42518769
Molecular Formula
C17H18ClN3O4S
Formula Weight
395.86
MOL File
1024448-59-6.mol
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1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine Property

Melting point:
109 - 113°C
storage temp. 
Store at +4°C
solubility 
DMSO: ≥10mg/mL
form 
powder
color 
light yellow to light tan
InChI
1S/C17H18ClN3O4S/c18-15-6-7-17(16(12-15)21(22)23)26(24,25)20-10-8-19(9-11-20)13-14-4-2-1-3-5-14/h1-7,12H,8-11,13H2
InChIKey
ZNLVYSJQUMALEO-UHFFFAOYSA-N
SMILES
[O-][N+](=O)c1cc(Cl)ccc1S(=O)(=O)N2CCN(CC2)Cc3ccccc3
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
WGK Germany 
1
Storage Class
11 - Combustible Solids
Hazard Classifications
Eye Irrit. 2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R1033
Product name
RN-1747
Purity
≥98% (HPLC)
Packaging
5mg
Price
$91.3
Updated
2025/07/31
Sigma-Aldrich
Product number
R1033
Product name
RN-1747
Purity
≥98% (HPLC)
Packaging
25mg
Price
$239
Updated
2025/07/31
Tocris
Product number
3745
Product name
RN1747
Purity
≥98%(HPLC)
Packaging
10
Price
$149
Updated
2021/12/16
Tocris
Product number
3745
Product name
RN1747
Purity
≥98%(HPLC)
Packaging
50
Price
$622
Updated
2021/12/16
TRC
Product number
R637008
Product name
RN1747
Packaging
100mg
Price
$360
Updated
2021/12/16
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1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine Chemical Properties,Usage,Production

Uses

RN 1747 is a novel TRPV4 modulator.

Biological Activity

TRPV4, a close relative of the vanilloid receptor TRPV1, is activated by diverse modalities such as endogenous lipid ligands, hypotonicity, protein kinases and, possibly, mechanical inputs. TRPV4 is a nociceptor playing an important role in inflammatory and neuropathic mechanical hyperalgesia in rodent models apparently specifically activated under pathological conditions.

storage

+4°C

1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine Suppliers

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1024448-59-6, 1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazineRelated Search:

Benzyl acetate Penicillin G

  • 1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine
  • RN 1747
  • 1-(4-Chloro-2-nitrophenyl)sulphonyl-4-benzylpiperazine (RN-1747)
  • 1-[(4-Chloro-2-nitrophenyl)sulfonyl]-4-(phenylmethyl)-piperazine
  • 1-benzyl-4-((4-chloro-2-nitrophenyl)sulfonyl)piperazine
  • Piperazine, 1-[(4-chloro-2-nitrophenyl)sulfonyl]-4-(phenylmethyl)-
  • RN-1747 >=98% (HPLC)
  • TRP Channel,RN-1747,Inhibitor,RN 1747,Transient receptor potential channels,RN1747,inhibit
  • 1-Benzyl-4-(4-Chloro-2-Nitrobenzenesulfonyl)Piperazine
  • RN-1747, 10 mM in DMSO
  • 1024448-59-6
  • 102448-59-6
  • C17H18CIN3O4S