N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide

ChemicalBook > CAS DataBase List > N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide

N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide

Product Name: N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide
CAS No.: 1130067-06-9
Chemical Name: N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide
Synonyms: CS-2781;VU 0155069;CAY10593 (VU0155069);VU-0155069,VU0155069;N-[1-[4-(5-CHLORO-2-OXO-3H-BENZIMIDAZOL-1-YL)PIPERIDIN-1-YL]PROPAN-2-YL]NAPHTHALENE-2-CARBOXAMIDE;(S)-N-(1-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propan-2-yl)-2-naphthamide;N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide;2-Naphthalenecarboxamide, N-[(1S)-2-[4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl]-;N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benziMidazol-1-yl)-1-piperidinyl]-1-Methylethyl-2-naphthalenecarboxaMide CAY10593 VU 0155069
CBNumber: CB42518789
Molecular Formula: C26H27CIN4O2.HCl
Formula Weight: 462.97
MOL File: 1130067-06-9.mol

Less

N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide Property

Density: 1.291±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: insoluble in EtOH; insoluble in H2O; ≥25.15 mg/mL in DMSO
form: Pale-yellow solid.
pka: 11.11±0.30(Predicted)
color: White to off-white

Less

Safety

HS Code: 2933998090

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 13206
Product name: VU0155069
Purity: ≥95%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 13206
Product name: VU0155069
Purity: ≥95%
Packaging: 5mg
Price: $98
Updated: 2024/03/01

Cayman Chemical

Product number: 13206
Product name: VU0155069
Purity: ≥95%
Packaging: 10mg
Price: $178
Updated: 2024/03/01

Cayman Chemical

Product number: 13206
Product name: VU0155069
Purity: ≥95%
Packaging: 25mg
Price: $353
Updated: 2024/03/01

Tocris

Product number: 3575
Product name: VU0155069
Purity: ≥98%(HPLC)
Packaging: 50
Price: $971
Updated: 2021/12/16

Less

N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide Chemical Properties,Usage,Production

Uses

VU0155069 is a potent and specific inhibitor of phospholipase D1.

Biological Activity

vu 0155069 is a selective phospholipase d1 (pld1) inhibitor, with an ic50 value of 46 nm [1].pld1 is one of the main pld isoforms in mammals. pld is an important enzyme responsible for the production of the lipid second messenger, i.e. phosphatidic acid which participates in both g protein-coupled receptor and receptor tyrosine kinase signal transduction networks [1].in calu-1 and hek293-gfppld2 cells, vu 0155069 blocked both pld1 and pld2 activity at the concentration of 20 μm, whilst preferentially inhibited pld1 at a lower concentration of 200 nm. in 4t1 cells, pld1-preferring vu 0155069 at 200 nm significantly decreased cell migration compared with the vehicle control [1].in mice bearing hepatocellular carcinoma xenografts, vu 0155069 (5 mg/kg, 50 μl, s.c., on alternate days) significantly reduced xenograft tumor size and weight. furthermore, vu 0155069 treatment substantially reduced both proliferating cell nuclear antigen- (pcna-) and ki67-positive cell populations in skin xenograft tumors [2].[1]. scott s a, selvy p e, buck j r, et al. design of isoform-selective phospholipase d inhibitors that modulate cancer cell invasiveness. nature chemical biology, 2009, 5(2): 108-117.[2]. xiao j, sun q, bei y, et al. therapeutic inhibition of phospholipase d1 suppresses hepatocellular carcinoma. clinical science, 2016, 130(13): 1125-1136.

N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

Less

N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide Suppliers

China 50 United Kingdom 1 United States 9 USA 1 Global 61

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4512
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7269
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1847
Advantage: 55

Changzhou Jiezhan Chemical Technology Co., Ltd

Tel: 15861130028
Email: 956912955@qq.com
Country: China
ProdList: 288
Advantage: 58

Syntechem Co.,Ltd.

Tel: 519-88298820 15861130028
Fax: 86-519-83850735
Email: info@syntechem.com
Country: China
ProdList: 242
Advantage: 58

Aikon International Limited

Tel: 025-66113011 18112977050
Fax: (5)02557626880
Email: cb6@aikonchem.com
Country: China
ProdList: 15494
Advantage: 58

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 1788
Advantage: 58

Jinan Yaoyan Pharmaceutical Co., Ltd.

Tel
Fax: -
Email: jnyaoyan@163.com
Country: China
ProdList: 3069
Advantage: 58

Aishilun biotechnology (Shanghai) co., LTD

Tel: 021-50676523 18019098996
Email: info@acelybio.com
Country: China
ProdList: 3960
Advantage: 58

Tianjin Kaifu Pharmaceutical Technology Co., Ltd.

Tel: 18081075745
Email: chemflowtech@sina.com
Country: China
ProdList: 1886
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19103
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Siyang Liaoning Biochemical Products Co. Ltd

Tel: +86-15221114306; +8615221114306
Fax: 86-417-4890038
Email: 2594582574@qq.com
Country: China
ProdList: 561
Advantage: 58

Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 918
Advantage: 58

Hefei fuya biotechnology co. LTD

Tel: 18096409024
Email: sales02@foreversyn.com
Country: China
ProdList: 1918
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11217
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44808
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10002
Advantage: 58

Changzhou Furuisi Biotechnology Co., Ltd

Tel: 0519-85524369
Email: 3477467573@qq.com
Country: China
ProdList: 8617
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44458
Advantage: 58

Abmole Bioscience Inc.

Tel: 021-50967598 02150967598
Email: sales@abmole.cn
Country: China
ProdList: 4494
Advantage: 58

Zhengzhou convergence chemical co., LTD

Tel: 0371-0371-55153829 18003835034
Fax: 18003835034（微信）
Email: 2853979819@qq.com
Country: China
ProdList: 9718
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

JinOu Biomedical (Nanjing) Co., Ltd.

Tel: 13000000000
Fax: jinoupharma@163
Email: jinoupharma@163.com
Country: China
ProdList: 11721
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 13774214275
Email: zhouzz@univ-bio.com
Country: China
ProdList: 24990
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62163
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24647
Advantage: 58

Suzhou Zhixin Biotechnology Co., Ltd.

Tel: 0512-65118909 15162312715
Email: sales@szzxbio.com
Country: China
ProdList: 2990
Advantage: 58

Nanjing Tengyi Biotechnology Co., Ltd

Tel: 025-58851786 17714337195
Email: sales@tybiochem.com
Country: China
ProdList: 6813
Advantage: 58

Shanghai?Medlife?Pharm-Tech?Co.,?Ltd

Tel: 021-59167510 18117107507
Email: vip@med-life.cn
Country: China
ProdList: 4997
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9272
Advantage: 58

Henan Allgreen Chemical Co.,LTD

Tel: +86-37155567971 +86-13633837469
Email: info@allgreenchem.com
Country: China
ProdList: 5983
Advantage: 58

Shanghai Silk Dragon Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 3988
Advantage: 58

Fujifilm Wako (Guangzhou) Trading Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 1409
Advantage: 58

Beijing Dongge Boye Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1861586486@qq.com
Country: CHINA
ProdList: 6648
Advantage: 58

Shanghai Haoran Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 470003480@QQ.COM
Country: CHINA
ProdList: 6955
Advantage: 58

Beijing Lebo Biotechnology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6057
Advantage: 58

Shanghai Yaoyun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 912529879@qq.com
Country: CHINA
ProdList: 6835
Advantage: 58

Shanghai Minmin Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1914109725@qq.com
Country: CHINA
ProdList: 6518
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6906
Advantage: 58

Beijing Fubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: info@f-biology.com
Country: CHINA
ProdList: 6025
Advantage: 58

Shanghai Benrui Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: john.st@163.com
Country: CHINA
ProdList: 1471
Advantage: 58

Shanghai Ziqi Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 2453006496@qq.com
Country: CHINA
ProdList: 6184
Advantage: 58

Shenzhen Xinbosheng Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: service@neobioscience.com
Country: CHINA
ProdList: 6151
Advantage: 58

Morning Student Science and Technology (Guangzhou) Co., Ltd.

Tel: --
Fax: --
Email: chenxue_gz@163.com
Country: CHINA
ProdList: 6600
Advantage: 58

1130067-06-9, N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamideRelated Search:

VU 591 hydrochloride VU0155041 2-Naphthalenecarboxamide, N-[(1S)-2-[4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl]-, hydrochloride (1:1) N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide 7,13-Bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecanedihydrochloride [2-(3,4-dimethylphenyl)-3-pyrrol-1-yl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]-pyrazin-2-ylmethanone N[2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]quinoline-3-carboxamide Hydrochloride

N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide

VU 0155069

CS-2781

(S)-N-(1-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propan-2-yl)-2-naphthamide

CAY10593 (VU0155069)

N-[1-[4-(5-CHLORO-2-OXO-3H-BENZIMIDAZOL-1-YL)PIPERIDIN-1-YL]PROPAN-2-YL]NAPHTHALENE-2-CARBOXAMIDE

2-Naphthalenecarboxamide, N-[(1S)-2-[4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl]-

N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benziMidazol-1-yl)-1-piperidinyl]-1-Methylethyl-2-naphthalenecarboxaMide CAY10593 VU 0155069

VU-0155069,VU0155069

1130067-06-9

C26H27ClN4O2HCl

C26H27CIN4O2HCl