Kisspeptin 234

Product Name: Kisspeptin 234
CAS No.: 1145998-81-7
Chemical Name: Kisspeptin 234
Synonyms: Kisspeptin 234;Kisspeptin 234 acetate;L-Phenylalaninamide, N-acetyl-D-alanyl-L-asparaginyl-L-tryptophyl-L-asparaginylglycyl-L-phenylalanylglycyl-D-tryptophyl-L-arginyl-
CBNumber: CB42518794
Molecular Formula: C63H78N18O13
Formula Weight: 1295.41
MOL File: 1145998-81-7.mol

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Kisspeptin 234 Property

storage temp.: Store at -20°C
solubility: insoluble in DMSO; insoluble in EtOH; ≥4.44 mg/mL in H2O with ultrasonic
form: solid
color: White
Water Solubility: Soluble to 1 mg/ml in water
Sequence: Ac-d-Ala-Asn-Trp-Asn-Gly-Phe-Gly-d-Trp-Arg-Phe-NH2

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 3881
Product name: Kisspeptin234
Packaging: 1
Price: $150
Updated: 2021/12/16

ApexBio Technology

Product number: B5489
Product name: Kisspeptin234
Packaging: 1mg
Price: $219
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0004490
Product name: KISSPEPTIN 234
Purity: 95.00%
Packaging: 5MG
Price: $499.73
Updated: 2021/12/16

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Kisspeptin 234 Chemical Properties,Usage,Production

Uses

Kisspeptin 234, is a 10 amino acid peptide as well as a kisspeptin receptor (KISS1, GPR54) antagonist. Kisspeptin 234 is an analog of Kisspeptin 10[1].

Biological Activity

kisspeptin 234 is a kisspeptin receptor antagonist, with the ability to antagonize kisspeptin-10-induced activation of gpr-54. kisspeptin binds to its cognate receptor (i.e. gpr-54) on neurons that produce gonadotropin-releasing hormone (gnrh), and stimulates their activity, which in turn sends an obligatory signal for gnrh secretion, thereby gating down-stream events supporting reproduction. the development of kisspeptin receptor antagonists may provide a valuable tool for exploring the physiological and pathophysiological roles of kisspeptin in the regulation of reproduction, and could serve as a potential therapeutic agent for treating hormone-dependent disorders of reproduction, such as precocious puberty, endometriosis, as well as metastatic prostate cancer.1. roseweir ak, kauffman as, smith jt, et al. discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. journal of neuroscience, 2009, 29(12): 3920-3929.

in vivo

Kisspeptin 234 (1 mg/kg, ip, daily, 28 days) TFA can inhibit the anti-fibrotic effect of Kisspeptin-13 in the bleomycin (BLM)-induced lung fibrosis model of C57BL/6 mice, especially in weight loss, decreased survival rate, increased lung coefficient, and massive infiltration^[1].

storage

Store at -20°C

References

[1] Lei Z, et al. Kisspeptin?13 inhibits bleomycin?induced pulmonary fibrosis through GPR54 in mice. Mol Med Rep. 2019 Aug;20(2):1049-1056. DOI:10.3892/mmr.2019.10341

Kisspeptin 234 Preparation Products And Raw materials

Raw materials

Preparation Products

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Kisspeptin 234 Suppliers

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View Lastest Price from Kisspeptin 234 manufacturers

RongNa Biotechnology Co.,Ltd

Product: Kisspeptin 234 1145998-81-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2024-03-26

Shandong Hanjiang Chemical Co., Ltd

Product: Kisspeptin 1145998-81-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10T
Release date: 2024-01-10

1145998-81-7, Kisspeptin 234Related Search:

Kisspeptin 234

L-Phenylalaninamide, N-acetyl-D-alanyl-L-asparaginyl-L-tryptophyl-L-asparaginylglycyl-L-phenylalanylglycyl-D-tryptophyl-L-arginyl-

Kisspeptin 234 acetate

1145998-81-7

C63H78N18O13