N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide
- Product Name
- N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide
- CAS No.
- 244101-02-8
- Chemical Name
- N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide
- Synonyms
- CM 9;L-798,106;GW 671021;L798106,L 798106;N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide;(E)-N-((5-Bromo-2-methoxyphenyl)sulfonyl)-3-(2-(naphthalen-2-ylmethyl)phenyl)acrylamide;(2E)-N-[(5-BroMo-2-Methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylMethyl)phenyl]-2-propenaMide;2-Propenamide, N-[(5-bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-, (2E)-
- CBNumber
- CB42518855
- Molecular Formula
- C27H22BrNO4S
- Formula Weight
- 536.44
- MOL File
- 244101-02-8.mol
N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide Property
- Density
- 1.425±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >20mg/mL
- form
- powder
- pka
- 4.26±0.10(Predicted)
- color
- White to off-white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- L4545
- Product name
- L-798106
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $157
- Updated
- 2024/03/01
- Product number
- L4545
- Product name
- L-798106
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $620
- Updated
- 2024/03/01
- Product number
- 11129
- Product name
- L-798,106
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 11129
- Product name
- L-798,106
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 11129
- Product name
- L-798,106
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $172
- Updated
- 2024/03/01
N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide Chemical Properties,Usage,Production
Uses
L-798106 is a potent and selective prostanoid receptor EP3-selective antagonists. L-798106 has been used in multiple studies to tease out EP3 agonist activity, both in vitro and in vivo. L-798106 successfully blocks the actions of sulprostone, an EP3-selective agonist. L-798106 was useful in showing that the vascular contraction effect of PGE2 is due to its prostanoid EP3 agonist activity.
Uses
L-798106, a selective prostanoid receptor EP3 antagonist, is used in prostanoid receptor signaling studies that regulate COX-2 levels and the central excitatory effects of PGE(2) on PVN neurons.
Definition
ChEBI: L-798106 is an N-sulfonylcarboxamide resulting from the formal condensation of the carboxy group of o-naphthalen-2-ylcinnamic acid with the sulfonamide group of 5-bromo-2-methoxybenzenesulfonamide. It is a selective antagonist for the prostanoid receptor EP3, a prostaglandin receptor for prostaglandin E2 (PGE2). It has a role as a prostaglandin receptor antagonist. It is a N-sulfonylcarboxamide, a member of bromobenzenes and an aromatic ether.
Biochem/physiol Actions
L-798106 was among the first prostanoid receptor EP3-selective antagonists. It has been used in multiple studies to tease out EP3 agonist activity, both in vitro and in vivo. It successfully blocks the actions of sulprostone, an EP3-selective agonist, and it helped show that the vascular contraction effect of PGE2 is due to its prostanoid EP3 agonist activity.
storage
Store at RT