N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamidehydrochloride

Product Name: N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamidehydrochloride
CAS No.: 487051-12-7
Chemical Name: N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamidehydrochloride
Synonyms: SNAP-94847;SNAP-94847 >=98% (HPLC);SNAP 94847 hydrochloride;N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}piperidin-4-yl)-4-methylphenyl]-2-methylpropanamide;N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methyl-propanamide;Propanamide, N-[3-[1-[[4-(3,4-difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methyl-;N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamidehydrochloride
CBNumber: CB42518921
Molecular Formula: C29H32F2N2O2
Formula Weight: 478.57
MOL File: 487051-12-7.mol

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N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamidehydrochloride Property

storage temp.: Desiccate at RT
solubility: DMSO: soluble20mg/mL, clear
form: powder
color: white to beige

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Safety

Hazard Codes: N
Risk Statements: 50/53
Safety Statements: 60-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0830
Product name: SNAP-94847
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $146
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0830
Product name: SNAP-94847
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $558
Updated: 2025/07/31

Tocris

Product number: 3347
Product name: SNAP94847hydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $231
Updated: 2021/12/16

Tocris

Product number: 3347
Product name: SNAP94847hydrochloride
Purity: ≥98%(HPLC)
Packaging: 50
Price: $971
Updated: 2021/12/16

Usbiological

Product number: 256708
Product name: SNAP 94847 hydrochloride
Packaging: 10mg
Price: $480
Updated: 2021/12/16

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N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamidehydrochloride Chemical Properties,Usage,Production

Uses

SNAP 94847 Hydrochloride is an MCH1 antagonist.

Biological Activity

SNAP-94847 is a potent antagonist of the melanin-concentrating hormone receptor MCHR-1. SNAP-94847 displays anxiolytic and antidepressant activity, and reduces food intake in mice.

in vivo

SNAP 94847 (oral gavage; 20 mg/kg; 14 days) shows an exaggerated locomotor response to acute quinpirole [treatment: F(2,19)=11.31, treatment × time: F(34,323) = 4.061], the effect of SNAP 94847 on quinpirole-evoked ambulations over the entire observation period is significant compared to the untreated animals^[2]. SNAP 94847 (oral administration; 20 mg/kg; 21 days) in drink water, produces a significant increase in ambulation relative to untreated animals [treatment: F(3,28) = 8.971; treatment × time: F(51,476)=11.50]. shows a marked increase in locomotion is apparent after 40 min in the SNAP 94847-treated group,this effect is significant over 180 min^[2]. SNAP 94847 (oral administration; 10 mg/kg), has a good bioavailability (59%), low plasma and blood clearances of 4.2 L/hr/kg and 3.3 L/hr/kg, respectively, and the half-life was shown to be 5.2 h in rats in a PK study^[3].

Animal Model:	Rat^[2]
Dosage:	20?mg/kg
Administration:	Oral administration; 20?mg/kg; 14 days
Result:	Exhibited a exaggerated locomotor response to acute quinpirole.

Animal Model:	Rat (PK study)^[3]
Dosage:	10 mg/kg
Administration:	oral gavage; 10 mg/kg
Result:	Exhibited good physicochemical properties in rats.

N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamidehydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamidehydrochloride Suppliers

China 29 United Kingdom 1 United States 7 USA 1 Global 38

3B Pharmachem (Wuhan) International Co.,Ltd.

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Energy Chemical

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487051-12-7, N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamidehydrochlorideRelated Search:

N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamidehydrochloride

SNAP 94847 hydrochloride

N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methyl-propanamide

SNAP-94847

Propanamide, N-[3-[1-[[4-(3,4-difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methyl-

SNAP-94847 >=98% (HPLC)

N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}piperidin-4-yl)-4-methylphenyl]-2-methylpropanamide

487051-12-7

C29H32F2N2O2HCl

C29H32F2O2HCl

C29H32F2N2O2