ChemicalBook > CAS DataBase List > 2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride

2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride

Product Name
2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride
CAS No.
864289-85-0
Chemical Name
2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride
Synonyms
C-021;CCR4 Antagonist;C-021, 10 mM in DMSO;C 021 dihydrochloride;C-021 (CCR4 antagonist);4'-?bipiperidin]?-?1'-?yl-?N-?cycloheptyl-?6;2-(1,4'-Bipiperidin)-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine;4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy;2-([1,4'-Bipiperidin]-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine;2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride
CBNumber
CB42518956
Molecular Formula
C27H41N5O2.2HCl
Formula Weight
541
MOL File
864289-85-0.mol
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2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride Property

storage temp. 
Desiccate at RT
solubility 
Soluble in DMSO
form 
solid
color 
Pale yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21885
Product name
CCR4 Antagonist
Purity
≥98%
Packaging
1mg
Price
$46
Updated
2021/12/16
Cayman Chemical
Product number
21885
Product name
CCR4 Antagonist
Purity
≥98%
Packaging
5mg
Price
$150
Updated
2021/12/16
Tocris
Product number
3581
Product name
C021dihydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$229
Updated
2021/12/16
Tocris
Product number
3581
Product name
C021dihydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$961
Updated
2021/12/16
Usbiological
Product number
254845
Product name
C 021 dihydrochloride
Packaging
10mg
Price
$480
Updated
2021/12/16
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2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride Chemical Properties,Usage,Production

Biological Activity

c 021 dihydrochloride is a potent antagonist of ccr4 with ic50 values of 0.039 and 0.14 μm for inhibition of chemotaxis in mouse and human, respectively [1].cc chemokine receptor 4 (ccr4) is a g protein-coupled receptor and is a receptor for the cc chemokines, which play an important role in the development and function of the immune system.c 021 dihydrochloride is a potent ccr4 antagonist. c 021 dihydrochloride potently inhibited functional chemotaxis in mice and human with ic50 values of 0.039 and 0.14 μm, respectively. in the gtpγs-binding assay, c 021 dihydrochloride was active with ic50 value of 0.018 μm [1].treatment mice with azoxymethane (aom), which induced hepatic encephalopathy, aom significantly increased microglia activation and the concentrations of ccl2 in the liver, serum, and cortex. c 021 dihydrochloride reduced liver damage and significantly improved the neurological outcomes. also, c 021 dihydrochloride reduced microglia activation and phosphorylation of erk1/2, and inhibited aom-induced cytokine upregulation [2].

References

[1]. yokoyama k, ishikawa n, igarashi s, et al. potent and orally bioavailable ccr4 antagonists: synthesis and structure-activity relationship study of 2-aminoquinazolines. bioorg med chem, 2009, 17(1): 64-73.
[2]. mcmillin m, frampton g, thompson m, et al. neuronal ccl2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. j neuroinflammation, 2014, 11: 121.

2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride Suppliers

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864289-85-0, 2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochlorideRelated Search:


  • 2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride
  • C 021 dihydrochloride
  • CCR4 Antagonist
  • 4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy
  • C-021
  • 4'-?bipiperidin]?-?1'-?yl-?N-?cycloheptyl-?6
  • 2-(1,4'-Bipiperidin)-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine
  • Inhibitor,CCR,inhibit,CC chemokine receptor,CCL22,GTPγS,chemotaxis,CCR4,C-021,C021,C 021
  • 2-([1,4'-Bipiperidin]-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine
  • C-021 (CCR4 antagonist)
  • C-021, 10 mM in DMSO
  • 864289-85-0
  • C27H41N5O22HCl