ChemicalBook > CAS DataBase List > Chaetominine

Chaetominine

Product Name
Chaetominine
CAS No.
918659-56-0
Chemical Name
Chaetominine
Synonyms
CS-493;NSC746369;NSC 746369;NSC-746369;Chaetominine;(–)-Chaetominine;(-)-CHAETOMININE;Chaetominine (-)-Chaetominine;(2S,2a1S,4R,5AS)-5a-hydroxy-2-methyl-4-(4-oxoquinazolin-3(4H)-yl)-2a1,4,5,5a-tetrahydro-1H-2a;(2S,4R,5aS,9cS)-4,5,5a,9c-Tetrahydro-5a-hydroxy-2-methyl-4-(4-oxo-3(4H)-quinazolinyl)-3H-2a,9b-diazacyclopenta[jk]fluorene-1,3(2H)-dione
CBNumber
CB42521091
Molecular Formula
C22H18N4O4
Formula Weight
402.4
MOL File
918659-56-0.mol
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Chaetominine Property

Melting point:
164℃
Density 
1.63
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
A solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13135
Product name
(–)-Chaetominine
Purity
≥95%
Packaging
500μg
Price
$142
Updated
2024/03/01
Cayman Chemical
Product number
13135
Product name
(–)-Chaetominine
Purity
≥95%
Packaging
2.5mg
Price
$639
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
PXT0001712
Product name
CHAETOMININE
Purity
95.00%
Packaging
5MG
Price
$498.88
Updated
2021/12/16
AK Scientific
Product number
X5706
Product name
Chaetominine
Packaging
2.5mg
Price
$1005
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PXT0001712
Product name
CHAETOMININE
Purity
95.00%
Packaging
250MG
Price
$1867.95
Updated
2021/12/16
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Chaetominine Chemical Properties,Usage,Production

Description

(–)-Chaetominine is a cytotoxic alkaloid originally isolated from Chaetomium sp. IFB-E015. It inhibits the growth of K562 leukemia and SW1116 colon cancer cells (IC50s = 20 and 28 nM, respectively). (–)-Chaetominine induces apoptosis of K562 cells via upregulation of the Bax/Bcl-2 ratio, decreasing mitochondrial membrane potential, inducing mitochondrial cytochrome C release, and activation of caspase-3 and caspase-9. It also decreases doxorubicin efflux mediated by multidrug resistance-associated protein 1 (MRP1) and restores sensitivity to doxorubicin in resistant K562 cells.

Definition

ChEBI: Chaetominine is an organic heterotetracyclic compound that consists of 4,5,5a,9c-tetrahydro-3H-2a,9b-diazacyclopenta[jk]fluorene-1,3(2H)-dione substituted by a hydroxy group at position 5, a methyl group at position 2 and a 4-oxoquinazolin-3(4H)-yl group at position 4 (the 2S,4R,5aS,9cS stereoisomer). It is a cytotoxic alkaloid isolated from the endophytic fungus Chaetomium. It has a role as a metabolite. It is an organic heterotetracyclic compound, a member of quinazolines, a lactam and an indole alkaloid.

Chaetominine Preparation Products And Raw materials

Raw materials

Preparation Products

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Chaetominine Suppliers

China 23 China Hong Kong 1 United States 5 Global 29
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2784
Advantage
58
Xunteng International Trading Co.,Limited
Tel
Country
China Hong Kong
ProdList
878
Advantage
55
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2989
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28821
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6870
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 15093356674;
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30255
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
0519-85788828 13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3553
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11289
Advantage
58

918659-56-0, ChaetominineRelated Search:


  • Chaetominine
  • (2S,4R,5aS,9cS)-4,5,5a,9c-Tetrahydro-5a-hydroxy-2-methyl-4-(4-oxo-3(4H)-quinazolinyl)-3H-2a,9b-diazacyclopenta[jk]fluorene-1,3(2H)-dione
  • Chaetominine (-)-Chaetominine
  • (2S,2a1S,4R,5AS)-5a-hydroxy-2-methyl-4-(4-oxoquinazolin-3(4H)-yl)-2a1,4,5,5a-tetrahydro-1H-2a
  • (-)-CHAETOMININE
  • CS-493
  • 3H-2a,9b-Diazacyclopenta[jk]fluorene-1,3(2H)-dione, 4,5,5a,9c-tetrahydro-5a-hydroxy-2-methyl-4-(4-oxo-3(4H)-quinazolinyl)-, (2S,4R,5aS,9cS)-
  • (–)-Chaetominine
  • NSC 746369
  • NSC746369
  • NSC-746369
  • 918659-56-0