ChemicalBook > CAS DataBase List > 6-nitro-4-(trifluoromethyl)quinolin-2(1H)-one

6-nitro-4-(trifluoromethyl)quinolin-2(1H)-one

Product Name
6-nitro-4-(trifluoromethyl)quinolin-2(1H)-one
CAS No.
328956-38-3
Chemical Name
6-nitro-4-(trifluoromethyl)quinolin-2(1H)-one
Synonyms
6-Nitro-4-trifluoromethyl-1H-quinolin-2-one;6-nitro-4-(trifluoromethyl)quinolin-2(1H)-one;6-Nitro-4-(trifluoromethyl)-2(1H)-quinolinone;2(1H)-Quinolinone, 6-nitro-4-(trifluoromethyl)-;6-nitro-4-(trifluoromethyl)quinolin-2(1H)-one ISO 9001：2015 REACH
CBNumber
CB42524971
Molecular Formula
C10H5F3N2O3
Formula Weight
258.15
MOL File
328956-38-3.mol
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6-nitro-4-(trifluoromethyl)quinolin-2(1H)-one Property

Melting point:
284-285 °C(Solv: ethanol (64-17-5))
Boiling point:
368.7±42.0 °C(Predicted)
Density 
1.564±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
9.09±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
HCH0368147
Product name
6-NITRO-4-(TRIFLUOROMETHYL)QUINOLIN-2(1H)-ONE
Purity
95.00%
Packaging
5MG
Price
$496.11
Updated
2021/12/16
AK Scientific
Product number
3728AB
Product name
6-Nitro-4-(trifluoromethyl)quinolin-2(1H)-one
Packaging
100mg
Price
$139
Updated
2021/12/16
Chemcia Scientific
Product number
BB20-6665A
Product name
6-Nitro-4-trifluoromethyl-1H-quinolin-2-one
Purity
＞97%
Packaging
0.5g
Price
$195
Updated
2021/12/16
Ambeed
Product number
A281637
Product name
6-Nitro-4-(trifluoromethyl)quinolin-2(1H)-one
Purity
97%
Packaging
25g
Price
$245
Updated
2021/12/16
Chemenu
Product number
CM125023
Product name
6-nitro-4-(trifluoromethyl)quinolin-2(3H)-one
Purity
95%
Packaging
1g
Price
$251
Updated
2021/12/16
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6-nitro-4-(trifluoromethyl)quinolin-2(1H)-one Chemical Properties,Usage,Production

Uses

6-Nitro-4-(trifluoromethyl)-2(1H)-quinolinone is an intermediate in the synthesis of LGD-2226 (L397615), an orally active potent and selective androgen receptor modulator used in the treatment of muscle wasting and osteoporosis. Show to have an anabolic effect on muscle and bone tissue.

Synthesis

6-Nitro-4-trifluoromethylquinolin-2(1H)-one is obtained by nitration with 4-Trifluoromethylquinolin-2(1H)-one.
Experimental Procedure：A milky suspension of 33.0 g 4-Trifluoromethylquinolin-2(1H)-one in 200 mL H2SO4 was cooled in an ice-salt bath to -5°C. 14.3 g 70% HNO3 was added dropwise, keeping the internal temperature below 7°C. After addition was complete, the mixture was stirred at 0-10°C for 1 h and then after removal of the ice bath the temperature raised to room temperature within the next hours. The yellow solution was then poured onto 600 g crushed ice and kept standing/stirring for the next 12 h. The resulting two phases were separated and the organic phase equals a yellow slurry, which was filtered by suction. The resulting solid was washed with water and dried under vacuum. After crystallization of 20 g crude product in 1 L ethanol a nearly colorless solid (6-Nitro-4-trifluoromethylquinolin-2(1H)-one) (43%) was obtained.

6-nitro-4-(trifluoromethyl)quinolin-2(1H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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6-nitro-4-(trifluoromethyl)quinolin-2(1H)-one Suppliers

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328956-38-3, 6-nitro-4-(trifluoromethyl)quinolin-2(1H)-oneRelated Search:


  • 6-nitro-4-(trifluoromethyl)quinolin-2(1H)-one
  • 6-Nitro-4-trifluoromethyl-1H-quinolin-2-one
  • 2(1H)-Quinolinone, 6-nitro-4-(trifluoromethyl)-
  • 6-nitro-4-(trifluoromethyl)quinolin-2(1H)-one ISO 9001：2015 REACH
  • 6-Nitro-4-(trifluoromethyl)-2(1H)-quinolinone
  • 328956-38-3