5-Bromo-3-fluoro-2-(hydroxymethyl)pyridine
- Product Name
- 5-Bromo-3-fluoro-2-(hydroxymethyl)pyridine
- CAS No.
- 1206968-92-4
- Chemical Name
- 5-Bromo-3-fluoro-2-(hydroxymethyl)pyridine
- Synonyms
- 5-Bromo-3-fluoro-2-(hydro...;5-Bromo-3-fluoro-2-pyridinemethanol;(5-Bromo-3-fluoro-2-pyridyl)methanol;2-Pyridinemethanol, 5-bromo-3-fluoro-;(5-broMo-3-fluoropyridin-2-yl)Methanol;5-BroMo-3-fluoro-2-(hydroxyMethyl)pyridine
- CBNumber
- CB42525099
- Molecular Formula
- C6H5BrFNO
- Formula Weight
- 206.01
- MOL File
- 1206968-92-4.mol
5-Bromo-3-fluoro-2-(hydroxymethyl)pyridine Property
- Boiling point:
- 245.8±35.0 °C(Predicted)
- Density
- 1.762±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 12.35±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C6H5BrFNO/c7-4-1-5(8)6(3-10)9-2-4/h1-2,10H,3H2
- InChIKey
- NPFXRHRCWLBISH-UHFFFAOYSA-N
- SMILES
- C1(CO)=NC=C(Br)C=C1F
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B679243
- Product name
- 5-Bromo-3-fluoro-2-(hydroxymethyl)pyridine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC52069
- Product name
- 5-Bromo-3-fluoro-2-(hydroxymethyl)pyridine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $64
- Updated
- 2021/12/16
- Product number
- G14978
- Product name
- (5-Bromo-3-fluoropyridin-2-yl)methanol
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 068785
- Product name
- 5-Bromo-3-fluoro-2-(hydroxymethyl)pyridine
- Purity
- >95%
- Packaging
- 500mg
- Price
- $1412
- Updated
- 2021/12/16
- Product number
- G14978
- Product name
- (5-Bromo-3-fluoropyridin-2-yl)methanol
- Packaging
- 1g
- Price
- $270
- Updated
- 2021/12/16
5-Bromo-3-fluoro-2-(hydroxymethyl)pyridine Chemical Properties,Usage,Production
Synthesis
1211538-72-5
1206968-92-4
The general procedure for the synthesis of (5-bromo-3-fluoropyridin-2-yl)methanol using 5-bromo-3-fluoro-2-pyridinecarboxylic acid methyl ester as starting material was as follows: 5-bromo-3-fluoro-2-pyridinecarboxylic acid methyl ester (12.82 mmol) was dissolved in anhydrous ethanol (50.0 mL), followed by addition of sodium borohydride (64.1 mmol). The resulting suspension was heated to reflux and the reaction was maintained for 4 hours and then cooled to room temperature. The reaction mixture was concentrated under reduced pressure to remove the solvent and the residue was diluted with a mixture of saturated aqueous sodium bicarbonate and brine and subsequently extracted with ethyl acetate. The organic phases were combined, dried with anhydrous sodium sulfate, filtered and silica gel powder (about 3 g) was added and evaporated to dryness under reduced pressure. Purification by silica gel column chromatography (eluent: 10% ethyl acetate solution of hexane) afforded the target product (5-bromo-3-fluoropyridin-2-yl)methanol (2.27 g, 82% yield) as a white solid. Mass spectrum (electrospray ionization, positive ion mode) m/z: 205.9, 207.7 [M + H]+. 1H NMR (400 MHz, DMSO-d6) δ ppm: 4.55 (dd, J = 6.06, 2.27 Hz, 2H), 5.40 (t, J = 6.06 Hz, 1H), 8.15 (dd, J = 9.35, 1.77 Hz, 1H), 8.52-8.57 (m, 1H).
References
[1] Patent: WO2014/8223, 2014, A2. Location in patent: Page/Page column 133-134
5-Bromo-3-fluoro-2-(hydroxymethyl)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-3-fluoro-2-(hydroxymethyl)pyridine manufacturers
- Product
- (5-Bromo-3-fluoro-2-pyridyl)methanol 1206968-92-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-14