ChemicalBook > CAS DataBase List > 1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-fluoro-

1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-fluoro-

Product Name
1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-fluoro-
CAS No.
1034667-22-5
Chemical Name
1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-fluoro-
Synonyms
3-Amino-5-fluoro-1H-pyraz...;3-Amino-5-fluoropyrazolo[3,4-b]pyridine;5-FLUORO-2H-PYRAZOLO[3,4-B]PYRIDIN-3-AMINE;5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine;3-AMino-5-fluoro-1H-pyrazolo[3,4-b]pyridine;1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-fluoro-;5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-ylaMine
CBNumber
CB42525266
Molecular Formula
C6H5FN4
Formula Weight
152.13
MOL File
1034667-22-5.mol
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1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-fluoro- Property

Boiling point:
408.7±40.0 °C(Predicted)
Density 
1.604±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
9.71±0.40(Predicted)
Appearance
Light yellow to green yellow Solid
InChI
InChI=1S/C6H5FN4/c7-3-1-4-5(8)10-11-6(4)9-2-3/h1-2H,(H3,8,9,10,11)
InChIKey
UFONWAPOQPJJLL-UHFFFAOYSA-N
SMILES
C12NN=C(N)C1=CC(F)=CN=2
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific
Product number
PC53221
Product name
5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine
Packaging
250mg
Price
$70
Updated
2021/12/16
ChemScene
Product number
CS-0037437
Product name
5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine
Packaging
250mg
Price
$158
Updated
2021/12/16
AK Scientific
Product number
0832AA
Product name
5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine
Packaging
250mg
Price
$184
Updated
2021/12/16
Apolloscientific
Product number
PC53221
Product name
5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine
Packaging
1g
Price
$199
Updated
2021/12/16
ChemScene
Product number
CS-0037437
Product name
5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine
Packaging
100mg
Price
$95
Updated
2021/12/16
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1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-fluoro- Chemical Properties,Usage,Production

Synthesis

791644-48-9

1034667-22-5

The general procedure for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine from 2-chloro-5-fluoro nicotinonitrile was as follows: to a solution of 2-chloro-5-fluoro nicotinonitrile (50 g, 321.7 mmol) in 1-butanol (1 L) was added hydrazine monohydrate (150 mL, 3.2 mol) and the mixture was refluxed for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated. The resulting precipitate was washed sequentially with water (twice) and ether (twice) and subsequently dried under vacuum overnight to afford 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine (44 g, 88% yield) as a yellow solid.1H NMR (DMSO-d6, 300 MHz) data were as follows: δ 5.53 (s, 2H); 7.94 (dd, 1H); 8.35 (dd, 1H); 12.02 (s, 1H).

References

[1] Patent: WO2008/77086, 2008, A1. Location in patent: Page/Page column 56; 58
[2] Patent: WO2009/18415, 2009, A1. Location in patent: Page/Page column 35-37
[3] Patent: US2011/20377, 2011, A1. Location in patent: Page/Page column 12; 13
[4] Patent: WO2008/112642, 2008, A1. Location in patent: Page/Page column 51-52
[5] Patent: WO2008/112646, 2008, A1. Location in patent: Page/Page column 51

1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-fluoro- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-fluoro- Suppliers

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View Lastest Price from 1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-fluoro- manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-fluoro- 1034667-22-5
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-06-12
SHAANXI LIGHTE OPTOELECTRONICS MATERIAL CO., LTD
Product
5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine 1034667-22-5
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
10 tons
Release date
2023-03-02
Career Henan Chemical Co
Product
3-AMino-5-fluoro-1H-pyrazolo[3,4-b]pyridine 1034667-22-5
Price
US $6.60/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg -1000kg
Release date
2020-01-02

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