ChemicalBook > CAS DataBase List > 4-chloro-6-methoxyquinolin-7-ol

4-chloro-6-methoxyquinolin-7-ol

Product Name
4-chloro-6-methoxyquinolin-7-ol
CAS No.
205448-31-3
Chemical Name
4-chloro-6-methoxyquinolin-7-ol
Synonyms
Bedaquiline Impurity 133;4-chloro-6-methoxyquinolin-8-ol;4-Chloro-6-Methoxy-7-quinolinol;4-chloro-6-methoxyquinolin-7-ol;7-Quinolinol, 4-chloro-6-methoxy-;4-Chloro-7-hydroxy-6-Methoxyquinolin;4-chloro-6-methoxy-1H-quinolin-7-one;4-Chloro-6-methoxy-7-hydroxyquinoline;4-Chloro-7-hydroxy-6-methoxyquinoline
CBNumber
CB42526056
Molecular Formula
C10H8ClNO2
Formula Weight
209.63
MOL File
205448-31-3.mol
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4-chloro-6-methoxyquinolin-7-ol Property

Boiling point:
353℃
Density 
1.386
Flash point:
168℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
8.41±0.40(Predicted)
form 
solid
color 
White to light brown
InChI
InChI=1S/C10H8ClNO2/c1-14-10-4-6-7(11)2-3-12-8(6)5-9(10)13/h2-5,13H,1H3
InChIKey
NKWZPFHSWLSOON-UHFFFAOYSA-N
SMILES
N1C2C(=CC(OC)=C(O)C=2)C(Cl)=CC=1
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Safety

HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
C596690
Product name
4-Chloro-6-methoxyquinolin-7-ol
Packaging
100mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
X0263
Product name
4-Chloro-6-methoxyquinolin-7-ol
Packaging
250mg
Price
$33
Updated
2021/12/16
AK Scientific
Product number
J97452
Product name
4-Chloro-6-methoxyquinolin-7-ol
Packaging
1g
Price
$72
Updated
2021/12/16
Apolloscientific
Product number
OR903690
Product name
4-Chloro-6-methoxyquinolin-7-ol
Purity
95%
Packaging
250mg
Price
$76
Updated
2021/12/16
AK Scientific
Product number
X0263
Product name
4-Chloro-6-methoxyquinolin-7-ol
Packaging
1g
Price
$91
Updated
2021/12/16
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4-chloro-6-methoxyquinolin-7-ol Chemical Properties,Usage,Production

Chemical Properties

Brown solid

Synthesis

286371-49-1

205448-31-3

General procedure for the synthesis of 7-hydroxy-4-chloro-6-methoxyquinoline from 7-(benzyloxy)-4-chloro-6-methoxyquinoline: the compound 7-(benzyloxy)-4-chloro-6-methoxyquinoline (16 g, 53.37 mmol) was dissolved in trifluoroacetic acid (100 mL), and methanesulfonic acid (6.1 mL, 93.94 mmol) was added in one go. The reaction mixture was stirred under reflux conditions for 3 hours and subsequently cooled to room temperature. The solvent was removed by evaporation and the pH of the residue was adjusted to 7 with 2.5 N sodium hydroxide solution.The resulting solid was crushed into small pieces and the mixture was stirred vigorously for 2 hr. The solid was collected by filtration and dried under high vacuum to give 7-hydroxy-4-chloro-6-methoxyquinoline (11.3 g, yield = 100%) as a light brown solid.

References

[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 18, p. 5766 - 5779
[2] Patent: US2014/235634, 2014, A1. Location in patent: Paragraph 0356; 0362
[3] Patent: CN106749231, 2017, A. Location in patent: Paragraph 0080; 0081; 0092; 0093

4-chloro-6-methoxyquinolin-7-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-chloro-6-methoxyquinolin-7-ol manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
4-chloro-6-methoxyquinolin-7-ol 205448-31-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-chloro-6-methoxyquinolin-7-ol 205448-31-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
4-chloro-6-methoxyquinolin-7-ol 205448-31-3
Price
US $2.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100g , 1kg, 5kg , 50kg
Release date
2020-01-07

205448-31-3, 4-chloro-6-methoxyquinolin-7-olRelated Search:

λ-Cyhalothrin 2-Formylfuran-5-boronic acid EUGENOL ACETATE diloxanide

  • 4-chloro-6-methoxyquinolin-7-ol
  • 4-Chloro-6-Methoxy-7-quinolinol
  • 4-Chloro-7-hydroxy-6-methoxyquinoline
  • 4-Chloro-7-hydroxy-6-Methoxyquinolin
  • 7-Quinolinol, 4-chloro-6-methoxy-
  • 4-Chloro-6-methoxy-7-hydroxyquinoline
  • 4-chloro-6-methoxy-1H-quinolin-7-one
  • 4-chloro-6-methoxyquinolin-8-ol
  • Bedaquiline Impurity 133
  • 205448-31-3
  • 5448-31-3