2-Cyclopropylaminonicotinic acid
- Product Name
- 2-Cyclopropylaminonicotinic acid
- CAS No.
- 639807-18-4
- Chemical Name
- 2-Cyclopropylaminonicotinic acid
- Synonyms
- 3-Pyridinecarboxylic acid, 2-(cyclopropylamino)-
- CBNumber
- CB42535719
- Molecular Formula
- C9H10N2O2
- Formula Weight
- 178.19
- MOL File
- 639807-18-4.mol
2-Cyclopropylaminonicotinic acid Property
- Boiling point:
- 380.1±27.0 °C(Predicted)
- Density
- 1.437
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 1.82±0.36(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C999025
- Product name
- 2-(Cyclopropylamino)nicotinicacid
- Packaging
- 100mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 5058CR
- Product name
- 2-(Cyclopropylamino)nicotinicacid
- Packaging
- 250mg
- Price
- $74
- Updated
- 2021/12/16
- Product number
- OR958277
- Product name
- 2-Cyclopropylaminonicotinicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 5058CR
- Product name
- 2-(Cyclopropylamino)nicotinicacid
- Packaging
- 10g
- Price
- $232
- Updated
- 2021/12/16
- Product number
- OR958277
- Product name
- 2-Cyclopropylaminonicotinicacid
- Purity
- 95%
- Packaging
- 5g
- Price
- $335
- Updated
- 2021/12/16
2-Cyclopropylaminonicotinic acid Chemical Properties,Usage,Production
Synthesis
52583-90-1
639807-18-4
1. Potassium hydroxide (KOH) pellets are added to a reaction system containing a water (H2O)/isopropanol (IPA) mixture of 2-(cyclopropylamino)nicotinonitrile under vigorous stirring (45% potassium hydroxide solution may also be used instead). An exothermic phenomenon from room temperature to 40 °C was observed during the reaction. 2. The temperature of the reaction system was raised to 80°C and maintained under reflux conditions for about 12 hours. The progress of the reaction was monitored by high performance liquid chromatography (HPLC) and after complete consumption of the feedstock, the mixture was cooled down to 0-5 °C and the pH was adjusted to about 6 by slow dropwise addition of 37% hydrochloric acid (HCl) while controlling the temperature below 10 °C. 3. The product, 2-cyclopropylidene, was added to the reaction system at room temperature. 3. The product 2-cyclopropylaminonicotinic acid (2-CAN) precipitated as a white solid and was separated by vacuum filtration. The wet cake was washed with minimal water and dried under vacuum at 70-80 °C to a constant weight. The final product 2-CAN was 23.40 g in 91% yield.
References
[1] Patent: WO2016/118586, 2016, A1. Location in patent: Page/Page column 30
[2] Patent: US2004/2603, 2004, A1. Location in patent: Page 3
[3] Green Chemistry, 2017, vol. 19, # 13, p. 2986 - 2991
2-Cyclopropylaminonicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-Cyclopropylaminonicotinic acid Suppliers
- Tel
- --
- Fax
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- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
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View Lastest Price from 2-Cyclopropylaminonicotinic acid manufacturers
- Product
- 2-Cyclopropylaminonicotinic acid 639807-18-4
- Price
- US $35.00-25.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 Ton
- Release date
- 2023-11-16