1-bromo-3,4-difluoro-2-methoxybenzene
- Product Name
- 1-bromo-3,4-difluoro-2-methoxybenzene
- CAS No.
- 888318-22-7
- Chemical Name
- 1-bromo-3,4-difluoro-2-methoxybenzene
- Synonyms
- 6-Bromo-2,3-difluoroanisole;1-bromo-3,4-difluoro-2-methoxybenzene;Benzene, 1-bromo-3,4-difluoro-2-methoxy-
- CBNumber
- CB42536211
- Molecular Formula
- C7H5BrF2O
- Formula Weight
- 223.01
- MOL File
- 888318-22-7.mol
1-bromo-3,4-difluoro-2-methoxybenzene Property
- Boiling point:
- 195.7±35.0 °C(Predicted)
- Density
- 1.615±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C7H5BrF2O/c1-11-7-4(8)2-3-5(9)6(7)10/h2-3H,1H3
- InChIKey
- DNXSLLIDTGLIHX-UHFFFAOYSA-N
- SMILES
- C1(Br)=CC=C(F)C(F)=C1OC
Safety
- HS Code
- 2909309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FB161397
- Product name
- 1-Bromo-3,4-difluoro-2-methoxybenzene
- Packaging
- 1g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- PC900061
- Product name
- 1-Bromo-3,4-difluoro-2-methoxybenzene
- Purity
- 97%
- Packaging
- 250mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- J96494
- Product name
- 1-Bromo-3,4-difluoro-2-methoxybenzene
- Packaging
- 1g
- Price
- $114
- Updated
- 2021/12/16
- Product number
- FB161397
- Product name
- 1-Bromo-3,4-difluoro-2-methoxybenzene
- Packaging
- 2g
- Price
- $170
- Updated
- 2021/12/16
- Product number
- PC900061
- Product name
- 1-Bromo-3,4-difluoro-2-methoxybenzene
- Purity
- 97%
- Packaging
- 1g
- Price
- $204
- Updated
- 2021/12/16
1-bromo-3,4-difluoro-2-methoxybenzene Chemical Properties,Usage,Production
Synthesis
186590-23-8
74-88-4
888318-22-7
Step 1: Synthesis of 1-bromo-3,4-difluoro-2-methoxybenzene 6-Bromo-2,3-difluorophenol (3 g, 14 mmol) was slowly added to a suspension of sodium hydride (60%, 672 mg, 16.8 mmol) in N,N-dimethylformamide (14 mL) at 0 °C. After gas release ceased, iodomethane (3.0 g, 21 mmol) was slowly added to the reaction mixture. After addition, the reaction mixture was gradually warmed to room temperature and stirred continuously for 12 hours. After completion of the reaction, the reaction was quenched with saturated sodium chloride solution. The reaction mixture was extracted with ethyl acetate (2 x 20 mL). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: n-hexane/ethyl acetate=16/1) to afford the oily product 1-bromo-3,4-difluoro-2-methoxybenzene (2.4 g, 77% yield). 1H NMR (300 MHz, CDCl3): δ 7.26 (dt, J = 7.5, 2.4 Hz, 1H), 6.82 (dt, J = 9.2, 7.5 Hz, 1H), 4.00 (d, J = 1.5 Hz, 3H).
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 20, p. 8685 - 8699,15
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 20, p. 8685 - 8699
[3] Patent: US2015/246923, 2015, A1. Location in patent: Paragraph 1017
[4] Patent: WO2016/107832, 2016, A1. Location in patent: Page/Page column 69
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View Lastest Price from 1-bromo-3,4-difluoro-2-methoxybenzene manufacturers
- Product
- 1-bromo-3,4-difluoro-2-methoxybenzene 888318-22-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-30