5-bromo-4-cyclopropylpyrimidine
- Product Name
- 5-bromo-4-cyclopropylpyrimidine
- CAS No.
- 1346697-39-9
- Chemical Name
- 5-bromo-4-cyclopropylpyrimidine
- Synonyms
- 5-bromo-4-cyclopropylpyrimidine;Pyrimidine, 5-bromo-4-cyclopropyl-
- CBNumber
- CB42536857
- Molecular Formula
- C7H7BrN2
- Formula Weight
- 199.05
- MOL File
- 1346697-39-9.mol
5-bromo-4-cyclopropylpyrimidine Property
- Boiling point:
- 254.0±28.0 °C(Predicted)
- Density
- 1.657±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 0.95±0.16(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B418988
- Product name
- 5-bromo-4-cyclopropylpyrimidine
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- HCH0366990
- Product name
- 5-BROMO-4-CYCLOPROPYLPYRIMIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.59
- Updated
- 2021/12/16
- Product number
- 5161DL
- Product name
- 5-Bromo-4-cyclopropylpyrimidine
- Packaging
- 1g
- Price
- $735
- Updated
- 2021/12/16
- Product number
- 5161DL
- Product name
- 5-Bromo-4-cyclopropylpyrimidine
- Packaging
- 5g
- Price
- $2598
- Updated
- 2021/12/16
- Product number
- CM165894
- Product name
- 5-Bromo-4-cyclopropylpyrimidine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $547
- Updated
- 2021/12/16
5-bromo-4-cyclopropylpyrimidine Chemical Properties,Usage,Production
Synthesis
4595-59-9
23719-80-4
1346697-39-9
Preparation of 5-bromo-4-cyclopropylpyrimidine (11A): to a solution of 5-bromopyrimidine (3 g, 18.87 mmol) dissolved in ether (Et2O, 120 mL) and tetrahydrofuran (THF, 20 mL) was slowly added cyclopropylmagnesium bromide (39.6 mL, 19.81 mmol) at 0 °C. The reaction mixture was stirred at room temperature for 1 h. The reaction was quenched with water (0.340 mL, 18.87 mmol), followed by the addition of a THF (10 mL) solution of DDF (4.28 g, 18.87 mmol). The resulting black mixture was continued to stir overnight at room temperature. After completion of the reaction, the reaction mixture was extracted with ethyl acetate (EtOAc). The aqueous layer was again extracted with EtOAc and the organic layers were combined and washed sequentially with 1N NaOH solution and brine. The crude product was purified by BIOTAGE system (elution gradient: 0-15% EtOAc/hexane, elution volume 1.2 L) to afford the target compound 5-bromo-4-cyclopropylpyrimidine (700 mg, 20% yield) as a yellow solid. The product was characterized by 1H NMR (500 MHz, CDCl3): δ 8.87 (1H, s), 8.66 (1H, s), 2.40-2.56 (1H, m), 1.13-1.32 (4H, m).
References
[1] Patent: WO2012/15723, 2012, A1. Location in patent: Page/Page column 107; 108
[2] Patent: WO2012/9510, 2012, A1. Location in patent: Page/Page column 54; 55
[3] Patent: WO2013/49263, 2013, A1. Location in patent: Paragraph 00147; 00148
5-bromo-4-cyclopropylpyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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