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KD 5170

Product Name
KD 5170
CAS No.
940943-37-3
Chemical Name
KD 5170
Synonyms
KD 5170;KD5170; KD-5170;KD5170, HDAC inhibitor;S-(2-(6-(4-(3-(DiMethylaMino)propoxy)phenylsulfonaMido)pyridin-3-yl)-2-oxoethyl) ethanethioate;S-(2-{6-[({4-[3-(dimethylamino)propoxy]phenyl}sulfonyl)amino]-3-p Yridinyl}-2-oxoethyl) Ethanethioate;Ethanethioic acid, S-[2-[6-[[[4-[3-(dimethylamino)propoxy]phenyl]sulfonyl]amino]-3-pyridinyl]-2-oxoethyl] ester
CBNumber
CB42538280
Molecular Formula
C20H25N3O5S2
Formula Weight
451.56
MOL File
940943-37-3.mol
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KD 5170 Property

Boiling point:
637.9±65.0 °C(Predicted)
Density 
1.310±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
≥21.2 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
form 
solid
pka
9.29±0.28(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13214
Product name
KD 5170
Purity
≥98%
Packaging
1mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
13214
Product name
KD 5170
Purity
≥98%
Packaging
5mg
Price
$128
Updated
2024/03/01
Cayman Chemical
Product number
13214
Product name
KD 5170
Purity
≥98%
Packaging
10mg
Price
$202
Updated
2024/03/01
Cayman Chemical
Product number
13214
Product name
KD 5170
Purity
≥98%
Packaging
25mg
Price
$465
Updated
2024/03/01
Usbiological
Product number
255590
Product name
KD 5170
Packaging
10mg
Price
$466
Updated
2021/12/16
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KD 5170 Chemical Properties,Usage,Production

Description

KD 5170 is a mercaptoketone-based inhibitor of class I and II histone deacetylases (HDACs; IC50s = 20, 2,060, 75, 26, 950, 14, 85, 2,500, 150, and 18 nM for HDAC1-10, respectively). It exhibits broad spectrum antitumor activity in vitro and in vivo. KD 5170 increases the acetylation of histones and activates caspases 3, 8, and 9, leading to apoptosis in primary myeloma cells.

References

[1]. hassig ca, symons kt, guo x, et al. kd5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo. mol cancer ther, 2008, 7(5): 1054-1065.
[2]. payne je, bonnefous c, hassig ca, et al. identification of kd5170: a novel mercaptoketone-based histone deacetylase inhibitor. bioorg med chem lett, 2008, 18(23): 6093-6096.
[3]. feng r, ma h, hassig ca, et al. kd5170, a novel mercaptoketone-based histone deacetylase inhibitor, exerts antimyeloma effects by dna damage and mitochondrial signaling. mol cancer ther, 2008, 7(6): 1494-1505.

KD 5170 Preparation Products And Raw materials

Raw materials

Preparation Products

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KD 5170 Suppliers

China 39 India 1 United States 8 USA 1 Global 49
Chengdu HappySyn Pharmaceutical Technology Co., Ltd.
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028-85114309 15881143215
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liangli@happysyn.com
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China
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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025-66099280 17798518460
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(1)02557626880
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cfzhang@aikonchem.com
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China
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Beijin Yangguang Furui Chemical co.,Ltd.
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010-57495520 13521095525
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zhw512@foxmail.com
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China
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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China
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Shanghai Jizhi Biochemical Technology Co. Ltd.
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4009004166/18616739031 18616739031
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3007523370@qq.com
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China
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Aishilun biotechnology (Shanghai) co., LTD
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021-50676523 18019098996
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info@acelybio.com
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China
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Career Henan Chemica Co
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+86-0371-86658258 +8613203830695
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0371-86658258
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laboratory@coreychem.com
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China
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Henan Weituxi Chemical Technology Co., Ltd.
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0371-63284658 18135795563
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2885349392@qq.com
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Absin Bioscience Inc.
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021-38015121 15000105423
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China
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MedBioPharmaceutical Technology Inc
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021-69568360 18916172912
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order@med-bio.cn
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Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
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021-51816796-820 13611835272
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TargetMol Chemicals Inc.
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4008200310
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Guangdong Shengke Biochemical Technology Co., Ltd.
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189-25112307 18925113981
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China
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Shaanxi Xihua Chemical Industry Co., Ltd
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17691182729 13992773979
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ATK CHEMICAL COMPANY LIMITED
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Sichuan Biosynce Pharmatech Co., Ltd.
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LEAPCHEM CO., LTD.
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market18@leapchem.com
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Nanjing Doge Biomedical Technology Co., Ltd
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Shanghai Hao Zhun Biological Technology Co., Ltd.
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Beijing Fubo Biotechnology Co., Ltd.
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Shanghai Hao Biological Technology Co., Ltd.
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Beijing Dakco is Biotechnology Co., Ltd.
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Shanghai Machine Pure Industrial Co., Ltd.
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Beijing Bolide Biotechnology Co., Ltd.
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Beijing Baiao Innovation Technology Co., Ltd.
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View Lastest Price from KD 5170 manufacturers

Career Henan Chemica Co
Product
KD 5170 940943-37-3
Price
US $1.80/KG
Min. Order
1g
Purity
96%-99%
Supply Ability
1kg/10kg/100kg
Release date
2020-11-11

940943-37-3, KD 5170Related Search:


  • KD 5170
  • S-(2-(6-(4-(3-(DiMethylaMino)propoxy)phenylsulfonaMido)pyridin-3-yl)-2-oxoethyl) ethanethioate
  • KD5170; KD-5170
  • S-(2-{6-[({4-[3-(dimethylamino)propoxy]phenyl}sulfonyl)amino]-3-p Yridinyl}-2-oxoethyl) Ethanethioate
  • Ethanethioic acid, S-[2-[6-[[[4-[3-(dimethylamino)propoxy]phenyl]sulfonyl]amino]-3-pyridinyl]-2-oxoethyl] ester
  • KD5170, HDAC inhibitor
  • 940943-37-3