Edoxaban hydrochloride

Product Name: Edoxaban hydrochloride
CAS No.: 480448-29-1
Chemical Name: Edoxaban hydrochloride
Synonyms: Edoxaban Hcl;Edoxaban (HCl salt);Edoxaban hydrochloride;Edoxaban Monohydrochloride;N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide:hydrochloride;N1-(5-Chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide hydrochloride
CBNumber: CB42549583
Molecular Formula: C24H31Cl2N7O4S
Formula Weight: 584.51844
MOL File: 480448-29-1.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0013888
Product name: EDOXABAN HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $498.97
Updated: 2021/12/16

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Edoxaban hydrochloride Chemical Properties,Usage,Production

Description

Edoxaban (Lixiana), a direct inhibitor of Factor Xa (FXa) was approved by the Minister of Health, Labor, and Welfare in Japan in April 2011 for the prevention of venous thromboembolism (VTE) after major orthopedic surgery. Edoxaban inhibits hFXa with a Ki=0.56 nM. Edoxaban is a weak inhibitor of thrombin Ki=6000 nM, has >10,000 fold selectivity over other serine proteases in the coagulation cascade, and demonstrates selectivity over trypsin and chymotrypsin. The synthesis of this class of FXa inhibitors begins with assembly of the diaminocyclohexane scaffold, cis-t-butyl((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate. The free amine is coupled to the P1 group, 2-((5-chloropyridin-2-yl) amino)-2-oxoacetic acid. The Boc protecting group on the amine of the scaffold is removed and the resulting free amine is coupled to the P4 group, 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid.

Originator

Daiichi Pharmaceutical (Japan)

brand name

Lixiana

Edoxaban hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Edoxaban hydrochloride Suppliers

China 7 France 1 India 1 Global 9

SPIRO PHARMA

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Country: China
ProdList: 9254
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Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
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Nanjing crow LuNing pharmaceutical technology co., LTD

Tel: 13382066392
Country: CHINA
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CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49390
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TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24131
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480448-29-1, Edoxaban hydrochlorideRelated Search:

Edoxaban hydrochloride

N1-(5-Chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide hydrochloride

Edoxaban (HCl salt)

Edoxaban Monohydrochloride

Edoxaban Hcl

N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide:hydrochloride

480448-29-1

C24H30ClN7O4SHCl