4-(TrifluoroMethoxy)benzeneacetic acid ethyl ester
- Product Name
- 4-(TrifluoroMethoxy)benzeneacetic acid ethyl ester
- CAS No.
- 1206550-93-7
- Chemical Name
- 4-(TrifluoroMethoxy)benzeneacetic acid ethyl ester
- Synonyms
- Ethyl 2-(4-(trifluoromethoxy);ethyl 2-(4-(trifluoromethoxy)phenyl)acetate;4-(TrifluoroMethoxy)benzeneacetic acid ethyl ester;(4-Trifluoromethoxy-phenyl)-acetic acid ethyl ester;Benzeneacetic acid, 4-(trifluoromethoxy)-, ethyl ester
- CBNumber
- CB42549664
- Molecular Formula
- C11H11F3O3
- Formula Weight
- 248.2
- MOL File
- 1206550-93-7.mol
4-(TrifluoroMethoxy)benzeneacetic acid ethyl ester Property
- Boiling point:
- 240.6±35.0 °C(Predicted)
- Density
- 1.246±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to off-white Solid-Liquid Mixture
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H341Suspected of causing genetic defects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B434130
- Product name
- Ethyl2-(4-(Trifluoromethoxy)phenyl)acetate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 3422DT
- Product name
- Ethyl2-(4-(trifluoromethoxy)phenyl)acetate
- Packaging
- 10g
- Price
- $587
- Updated
- 2021/12/16
- Product number
- EE0607
- Product name
- (4-Trifluoromethoxy-phenyl)-aceticacidethylester
- Packaging
- 1g
- Price
- $661
- Updated
- 2021/12/16
- Product number
- EE0607
- Product name
- (4-Trifluoromethoxy-phenyl)-aceticacidethylester
- Packaging
- 5g
- Price
- $1728
- Updated
- 2021/12/16
- Product number
- CD12173961
- Product name
- Ethyl2-(4-(trifluoromethoxy)phenyl)acetate
- Purity
- 97%
- Packaging
- 25g
- Price
- $673
- Updated
- 2021/12/16
4-(TrifluoroMethoxy)benzeneacetic acid ethyl ester Chemical Properties,Usage,Production
Chemical Properties
light yellow liquid
Synthesis
64-17-5
4315-07-5
1206550-93-7
a) Concentrated sulfuric acid (0.484 mL, 9.08 mmol) was added slowly and dropwise to a solution of 2-(4-(trifluoromethoxy)phenyl)acetic acid (2.0 g, 9.08 mmol) in anhydrous ethanol (20 mL), which was subsequently heated to reflux and held for 5 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove the solvent and then diluted with ethyl acetate (100 mL). The diluted solution was washed sequentially with saturated sodium bicarbonate solution and saturated brine to remove acidic impurities and inorganic salts. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated again under reduced pressure to give the crude product. The crude product was purified by column chromatography (eluent: ethyl acetate/hexane, gradient elution, 0/100 to 20/80) to finally obtain ethyl 2-(4-(trifluoromethoxy)phenyl)acetate (2.06 g, 91% yield) as a yellow oil.
References
[1] Patent: US2011/136833, 2011, A1. Location in patent: Page/Page column 36
4-(TrifluoroMethoxy)benzeneacetic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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