WYE 354-d3

Product Name: WYE 354-d3
CAS No.: 1794791-66-4
Chemical Name: WYE 354-d3
Synonyms: WYE 354-d3;4-[6-[4-[[(Methoxy-d3)carbonyl]aMino]phenyl]-4-(4-Morpholinyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]-1-piperidinecarboxylic Acid Methyl Ester
CBNumber: CB42551409
Molecular Formula: C24H29N7O5
Formula Weight: 495.54
MOL File: 1794791-66-4.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: W950002
Product name: WYE354-d3
Packaging: 10mg
Price: $1760
Updated: 2021/12/16

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WYE 354-d3 Chemical Properties,Usage,Production

Uses

A labelled pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and Akt as the respective substrate (IC50 <200 nM; [ATP] = 100 μM) and effectively blocks cellular phosphorylation of S6K on T389 and Akt on S473 both in cultures and in a murine xenograft model, resulting in a significant suppression of PC3MM2-derived tumor growth (by 86% on day 7; 50 mg/kg, i.p twice per day) in vivo.

WYE 354-d3 Preparation Products And Raw materials

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WYE 354-d3 Suppliers

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1794791-66-4, WYE 354-d3Related Search:

WYE-354 N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea WYE-687

WYE 354-d3

4-[6-[4-[[(Methoxy-d3)carbonyl]aMino]phenyl]-4-(4-Morpholinyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]-1-piperidinecarboxylic Acid Methyl Ester

1794791-66-4

C24H26D3N7O5

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Protein Kinase Inhibitors and Activators