5-chloro-1-Methyl-4-nitro-1H-pyrazole

Application

Product Name: 5-chloro-1-Methyl-4-nitro-1H-pyrazole
CAS No.: 42098-25-9
Chemical Name: 5-chloro-1-Methyl-4-nitro-1H-pyrazole
Synonyms: 100082;5-Chloro-1-methyl-4-nitropyrazole;5-chloro-1-Methyl-4-nitro-1H-pyrazole;5-CHLORO-1-METHYL-4-NITRO-1H-IMADAZOLE;1H-Pyrazole, 5-chloro-1-Methyl-4-nitro-;5-Chloro-1-methyl-4-nitro-1H-pyrazole 97%
CBNumber: CB42552734
Molecular Formula: C4H4ClN3O2
Formula Weight: 161.55
MOL File: 42098-25-9.mol

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5-chloro-1-Methyl-4-nitro-1H-pyrazole Property

Melting point:: 135-137℃
Boiling point:: 273℃
Density: 1.65
Flash point:: 119℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -3.31±0.10(Predicted)
Appearance: White to yellow Solid

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Safety

HS Code: 29331990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C993430
Product name: 5-Chloro-1-methyl-4-nitro-1H-pyrazole
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C993430
Product name: 5-Chloro-1-methyl-4-nitro-1H-pyrazole
Packaging: 100mg
Price: $90
Updated: 2021/12/16

TRC

Product number: C993430
Product name: 5-Chloro-1-methyl-4-nitro-1H-pyrazole
Packaging: 500mg
Price: $310
Updated: 2021/12/16

ChemScene

Product number: CS-B1287
Product name: 5-chloro-1-methyl-4-nitro-1H-pyrazole
Purity: ≥98.0%
Packaging: 250mg
Price: $62
Updated: 2021/12/16

AK Scientific

Product number: X5554
Product name: 5-Chloro-1-methyl-4-nitro-1H-pyrazole
Packaging: 100mg
Price: $123
Updated: 2021/12/16

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5-chloro-1-Methyl-4-nitro-1H-pyrazole Chemical Properties,Usage,Production

Application

5-Chloro-1-methyl-4-nitropyrazole can be used as an organic synthesis intermediate and a pharmaceutical intermediate in laboratory research and development processes and in the synthesis of pharmaceutical chemicals.

Synthesis

3994-50-1

42098-25-9

Example 1: General procedure for the synthesis of 5-chloro-1-methyl-4-nitro-1H-pyrazole from 1-methyl-4-nitropyrazole (a) Synthesis of 5-chloro-1-methyl-4-nitro-1H-pyrazole A THF solution of lithium bis(trimethylsilyl)amide (1.0 M, 65 mL, 65 mmol) was slowly added dropwise to a solution of dichloromethane (120 mL) containing 1-methyl-4-nitro-1H-pyrazole (5.50 g, 43.3 mmol) and hexachloroethane (10.54 g, 44.5 mmol) at 25 °C. The reaction mixture was stirred continuously at 25 °C for 60 min, followed by quenching the reaction with 1 mL of water. The mixture was concentrated to dryness and the residue was washed sequentially with 50 mL of water, saturated NaHCO3 solution (2 x 30 mL) and 30 mL of brine, and finally dried under vacuum to give 6.50 g of the target product in 93% yield. MS(ESI) m/z: 162.0 [M+H]+. 1H NMR (500MHz, CDCl3) δ: 8.15 (s, 1H), 3.92 (s, 3H).

References

[1] Patent: WO2016/90380, 2016, A1. Location in patent: Paragraph 0021
[2] Patent: US2015/57265, 2015, A1. Location in patent: Paragraph 0714
[3] Patent: CN108373476, 2018, A. Location in patent: Paragraph 0237-0239; 0242; 0243; 0290; 0294
[4] Patent: US2011/251176, 2011, A1. Location in patent: Page/Page column 103
[5] Patent: US2013/79321, 2013, A1. Location in patent: Paragraph 0177; 0178; 0179

5-chloro-1-Methyl-4-nitro-1H-pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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5-chloro-1-Methyl-4-nitro-1H-pyrazole Suppliers

China 87 India 1 United Kingdom 1 United States 3 Global 92

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42098-25-9, 5-chloro-1-Methyl-4-nitro-1H-pyrazoleRelated Search:

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5-chloro-1-Methyl-4-nitro-1H-pyrazole

100082

5-Chloro-1-methyl-4-nitropyrazole

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5-Chloro-1-methyl-4-nitro-1H-pyrazole 97%

5-CHLORO-1-METHYL-4-NITRO-1H-IMADAZOLE

42098-25-9