AMG-208

Product Name: AMG-208
CAS No.: 1002304-34-8
Chemical Name: AMG-208
Synonyms: CS-191;AMG-208;AMG-208, >=98%;AMG-208 ，S1316;AMG208; AMG 208;AMG-208 USP/EP/BP;AMG-208;AMG208; AMG 208;7-Methoxy-4-[(6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline;Quinoline, 7-Methoxy-4-[(6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)Methoxy]-;7-Methoxy-4-[(6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline AMG 208
CBNumber: CB42561457
Molecular Formula: C22H17N5O2
Formula Weight: 383.4
MOL File: 1002304-34-8.mol

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AMG-208 Property

Density: 1.34
storage temp.: Store at -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥3.83 mg/mL in DMSO
form: solid
pka: 5.98±0.27(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 24197
Product name: AMG 208
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 24197
Product name: AMG 208
Purity: ≥98%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 24197
Product name: AMG 208
Purity: ≥98%
Packaging: 10mg
Price: $356
Updated: 2024/03/01

Cayman Chemical

Product number: 24197
Product name: AMG 208
Purity: ≥98%
Packaging: 25mg
Price: $751
Updated: 2024/03/01

TRC

Product number: A576533
Product name: amg208
Packaging: 5mg
Price: $330
Updated: 2021/12/16

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AMG-208 Chemical Properties,Usage,Production

Uses

AMG-208 is an orally active c-Met/RON dual selective inhibitor with an IC50 of 9 nM for c-Met. AMG-208 is a CYP3A4 inhibitor with an IC50 of 32 μM. AMG-208 has anti-cancer activity[1][2][3].

Definition

ChEBI: A member of the class of quinolines that is 7-methoxyquinoline substituted at position 4 by a (6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy group. AMG exhibits antitumour activity, particularly in prostate cancer.

in vivo

In male Sprague Dawley rats, AMG-208 (0.5 mg/kg i.v.) shows a high bioavailability with Cl of 0.37 L/h/kg, Vss of 0.38 L/kg and T1/2 of 1 hour^[1].

target

Met

IC 50

CYP3A4: 32 μM (IC₅₀); c-Met: 9 nM (IC₅₀)

References

[1] Albrecht BK, et al. Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase. J Med Chem. 2008, 51(10), 2879-2882. DOI:10.1021/jm800043g
[2] Boezio AA, et al. Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors. Bioorg Med Chem Lett. 2009, 19(22), 6307-6312. DOI:10.1016/j.bmcl.2009.09.096
[3] Liu X, et al. Developing c-MET pathway inhibitors for cancer therapy: progress and challenges. Trends Mol Med. 2010,16(1), 37-45. DOI:10.1016/j.molmed.2009.11.005

AMG-208 Preparation Products And Raw materials

Raw materials

Preparation Products

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AMG-208 Suppliers

China 115 United States 16 Global 131

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
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Chembest Research Laboratories Limited

Tel: +86-21-20908456
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Email: sales@BioChemBest.com
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Jinan Trio PharmaTech Co., Ltd.

Tel: 0531-88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com
Country: China
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BOC Sciences

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Email: info@bocsci.com
Country: United States
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
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NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
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AdooQ BioScience, LLC

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Fax: +1 (866) 333-9607
Email: info@adooq.com
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ShangHai YingYi Chemical Technology Co., Ltd.

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Fax: 86-21-50700185
Email: sale@inyelchem.com
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CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
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View Lastest Price from AMG-208 manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: AMG-208 1002304-34-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

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AMG-208

7-Methoxy-4-[(6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline

AMG-208;AMG208; AMG 208

Quinoline, 7-Methoxy-4-[(6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)Methoxy]-

7-Methoxy-4-[(6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline AMG 208

AMG-208, >=98%

CS-191

AMG208; AMG 208

AMG-208 USP/EP/BP

AMG-208 ，S1316

1002304-34-8

Inhibitors