BS-181 hydrochloride

Product Name: BS-181 hydrochloride
CAS No.: 1092443-52-1
Chemical Name: BS-181 hydrochloride
Synonyms: BS 181;CS-507;CS-2137;BS-181 HCl;BS-181 free base;BS-181 hydrochloride;N5-(6-Aminohexyl)-3-isopropyl-N7-benzylpyrazolo[1,5-a]pyrimidine-5,7-diamine;Pyrazolo[1,5-a]pyrimidine-5,7-diamine, N5-(6-aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)-;5-N-(6-aminohexyl)-7-N-benzyl-3-propan-2-ylpyrazolo[1,5-a]pyrimidine-5,7-diamine,hydrochloride
CBNumber: CB42561462
Molecular Formula: C22H32N6
Formula Weight: 380.53
MOL File: 1092443-52-1.mol

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BS-181 hydrochloride Property

Density: 1.16
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 10.62±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17996
Product name: BS-181
Purity: ≥98%
Packaging: 1mg
Price: $35
Updated: 2021/12/16

Cayman Chemical

Product number: 17996
Product name: BS-181
Purity: ≥98%
Packaging: 5mg
Price: $158
Updated: 2021/12/16

Cayman Chemical

Product number: 17996
Product name: BS-181
Purity: ≥98%
Packaging: 10mg
Price: $280
Updated: 2021/12/16

Cayman Chemical

Product number: 17996
Product name: BS-181
Purity: ≥98%
Packaging: 50mg
Price: $963
Updated: 2021/12/16

ApexBio Technology

Product number: A3266
Product name: BS-181
Packaging: 5mg
Price: $100
Updated: 2021/12/16

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BS-181 hydrochloride Chemical Properties,Usage,Production

Uses

BS-181 is a potent and selective CDK7 inhibitor (IC50=21 nM) than Seliciclib (HY-30237). BS-181 is also against CDK2, CDK5 and CDK9 with IC50 values of 880, 3000 and 4200 nM, respectively (fails to block CDK1, 4 and 6). BS-181 inhibits a panel of cancer cells growth (IC50=11.5 μM-37.3 μM) and induces cell apoptosis. BS-181 has the potential for the research of cancer therapy[1][2].

Definition

ChEBI: N5-(6-aminohexyl)-N7-(phenylmethyl)-3-propan-2-ylpyrazolo[1,5-a]pyrimidine-5,7-diamine is a pyrazolopyrimidine.

in vivo

BS-181 (intraperitoneal injection; 5 mg/kg or 10 mg/kg twice daily; total daily doses of 10 mg/kg or 20 mg/kg; 14 days) inhibitstumor growth in a dose-dependent manner.?Tumor growth exhibits 25% and 50% reduction compared with the control group, for 10 mg/kg/day and 20 mg/kg/day, respectively^[1].

Animal Model:	7-week old female nu/nu-BALB/c athymic nude mice?with MCF-7 cells^[1]
Dosage:	5 mg/kg or 10 mg/kg; 10 mg/kg or 20 mg/kg
Administration:	Intraperitoneal injection; twice daily or once total daily; 14 days
Result:	Inhibited tumor growth significantly.

IC 50

CDK7/CycH/MAT1: 0.021 μM (IC₅₀); CDK2/Cyc E: 0.88 μM (IC₅₀); CDK5/p35NCK: 3 μM (IC₅₀); CDK9/cycT: 4.2 μM (IC₅₀); CDK1/cycB: 8.1 μM (IC₅₀); CDK4/Cyc D1: 33 μM (IC₅₀); CDK6/cycD1: 47 μM (IC₅₀)

References

[1] Ali S et al. The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 2009 Aug 1;69(15):6208-15. DOI:10.1158/0008-5472.CAN-09-0301
[2] Wang BY, et al. Selective CDK7 inhibition with BS-181 suppresses cell proliferation and induces cell cycle arrest and apoptosis in gastric cancer. Drug Des Devel Ther. 2016 Mar 16;10:1181-9. DOI:10.2147/DDDT.S86317

BS-181 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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BS-181 hydrochloride Suppliers

CHINA 96 France 1 United States 11 Global 108

Shanghai Boyle Chemical Co., Ltd.

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Shanghaizehan biopharma technology co., Ltd.

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View Lastest Price from BS-181 hydrochloride manufacturers

Career Henan Chemical Co

Product: BS-181 hydrochloride 1092443-52-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-30

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BS-181 free base

CS-2137

CS-507

5-N-(6-aminohexyl)-7-N-benzyl-3-propan-2-ylpyrazolo[1,5-a]pyrimidine-5,7-diamine,hydrochloride

BS-181 hydrochloride

BS 181

N5-(6-Aminohexyl)-3-isopropyl-N7-benzylpyrazolo[1,5-a]pyrimidine-5,7-diamine

BS-181 HCl

Pyrazolo[1,5-a]pyrimidine-5,7-diamine, N5-(6-aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)-

1092443-52-1

Inhibitors