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BS-181 hydrochloride

Product Name
BS-181 hydrochloride
CAS No.
1092443-52-1
Chemical Name
BS-181 hydrochloride
Synonyms
BS 181;CS-507;CS-2137;BS-181 HCl;BS-181 free base;BS-181 hydrochloride;N5-(6-Aminohexyl)-3-isopropyl-N7-benzylpyrazolo[1,5-a]pyrimidine-5,7-diamine;Pyrazolo[1,5-a]pyrimidine-5,7-diamine, N5-(6-aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)-;5-N-(6-aminohexyl)-7-N-benzyl-3-propan-2-ylpyrazolo[1,5-a]pyrimidine-5,7-diamine,hydrochloride
CBNumber
CB42561462
Molecular Formula
C22H32N6
Formula Weight
380.53
MOL File
1092443-52-1.mol
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BS-181 hydrochloride Property

Density 
1.16
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
10.62±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17996
Product name
BS-181
Purity
≥98%
Packaging
1mg
Price
$35
Updated
2021/12/16
Cayman Chemical
Product number
17996
Product name
BS-181
Purity
≥98%
Packaging
5mg
Price
$158
Updated
2021/12/16
Cayman Chemical
Product number
17996
Product name
BS-181
Purity
≥98%
Packaging
10mg
Price
$280
Updated
2021/12/16
Cayman Chemical
Product number
17996
Product name
BS-181
Purity
≥98%
Packaging
50mg
Price
$963
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0000936
Product name
BS-181 HYDROCHLORIDE
Purity
95.00%
Packaging
10MG
Price
$1006.58
Updated
2021/12/16
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BS-181 hydrochloride Chemical Properties,Usage,Production

Uses

BS-181 is a potent and selective CDK7 inhibitor (IC50=21 nM) than Seliciclib (HY-30237). BS-181 is also against CDK2, CDK5 and CDK9 with IC50 values of 880, 3000 and 4200 nM, respectively (fails to block CDK1, 4 and 6). BS-181 inhibits a panel of cancer cells growth (IC50=11.5 μM-37.3 μM) and induces cell apoptosis. BS-181 has the potential for the research of cancer therapy[1][2].

Definition

ChEBI: N5-(6-aminohexyl)-N7-(phenylmethyl)-3-propan-2-ylpyrazolo[1,5-a]pyrimidine-5,7-diamine is a pyrazolopyrimidine.

in vivo

BS-181 (intraperitoneal injection; 5 mg/kg or 10 mg/kg twice daily; total daily doses of 10 mg/kg or 20 mg/kg; 14 days) inhibitstumor growth in a dose-dependent manner.?Tumor growth exhibits 25% and 50% reduction compared with the control group, for 10 mg/kg/day and 20 mg/kg/day, respectively[1].

Animal Model:7-week old female nu/nu-BALB/c athymic nude mice?with MCF-7 cells[1]
Dosage:5 mg/kg or 10 mg/kg; 10 mg/kg or 20 mg/kg
Administration:Intraperitoneal injection; twice daily or once total daily; 14 days
Result:Inhibited tumor growth significantly.

IC 50

CDK7/CycH/MAT1: 0.021 μM (IC50); CDK2/Cyc E: 0.88 μM (IC50); CDK5/p35NCK: 3 μM (IC50); CDK9/cycT: 4.2 μM (IC50); CDK1/cycB: 8.1 μM (IC50); CDK4/Cyc D1: 33 μM (IC50); CDK6/cycD1: 47 μM (IC50)

References

[1] Ali S et al. The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 2009 Aug 1;69(15):6208-15. DOI:10.1158/0008-5472.CAN-09-0301
[2] Wang BY, et al. Selective CDK7 inhibition with BS-181 suppresses cell proliferation and induces cell cycle arrest and apoptosis in gastric cancer. Drug Des Devel Ther. 2016 Mar 16;10:1181-9. DOI:10.2147/DDDT.S86317

BS-181 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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BS-181 hydrochloride Suppliers

CHINA 96 France 1 United States 11 Global 108
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
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12952
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65
MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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AdooQ BioScience, LLC
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+1 (866) 930-6790
Fax
+1 (866) 333-9607
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info@adooq.com
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United States
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Target molecule Corp.
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857-239-0968
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857-239-8801
Email
service1@targetmol.com
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Musechem
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+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
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United States
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4660
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
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United States
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32435
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58
InvivoChem
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+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
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United States
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Cckinase, Inc.
Tel
+1 (732)236-3202
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sales@cckinase.com
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United States
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2738
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ApexBio Technology
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sales@apexbt.com
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United States
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Santa Cruz Biotechnology, Inc.
Tel
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scbt@scbt.com
Country
United States
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3597
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Cayman Chemical Company
Tel
--
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Email
cayman@caymanchem.com
Country
United States
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View Lastest Price from BS-181 hydrochloride manufacturers

Career Henan Chemical Co
Product
BS-181 hydrochloride 1092443-52-1
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-30

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  • BS-181 free base
  • CS-2137
  • CS-507
  • 5-N-(6-aminohexyl)-7-N-benzyl-3-propan-2-ylpyrazolo[1,5-a]pyrimidine-5,7-diamine,hydrochloride
  • BS-181 hydrochloride
  • BS 181
  • N5-(6-Aminohexyl)-3-isopropyl-N7-benzylpyrazolo[1,5-a]pyrimidine-5,7-diamine
  • BS-181 HCl
  • Pyrazolo[1,5-a]pyrimidine-5,7-diamine, N5-(6-aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)-
  • 1092443-52-1
  • Inhibitors