ChemicalBook > CAS DataBase List > Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl-

Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl-

Product Name
Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl-
CAS No.
69819-86-9
Chemical Name
Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl-
Synonyms
Darinaparsin;SP02);ZIO 101;EOS-60608;Selurampanel;Darinaparsin (ZIO101;Dimethylarsinic glutathione;Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl-
CBNumber
CB42563431
Molecular Formula
C12H22AsN3O6S
Formula Weight
411.3
MOL File
69819-86-9.mol
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Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl- Property

storage temp. 
Store at -20°C
solubility 
DMSO:10.0(Max Conc. mg/mL);24.31(Max Conc. mM)
form 
A crystalline solid
pka
2.21±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21659
Product name
Darinaparsin
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21659
Product name
Darinaparsin
Purity
≥95%
Packaging
5mg
Price
$131
Updated
2024/03/01
Cayman Chemical
Product number
21659
Product name
Darinaparsin
Purity
≥95%
Packaging
10mg
Price
$214
Updated
2024/03/01
Cayman Chemical
Product number
21659
Product name
Darinaparsin
Purity
≥95%
Packaging
25mg
Price
$420
Updated
2024/03/01
TRC
Product number
D193425
Product name
Darinaparsin
Packaging
250mg
Price
$765
Updated
2021/12/16
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Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl- Chemical Properties,Usage,Production

Description

Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 μM) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 μM), as well as Jurkat T cell lymphoma and L540 Hodgkin lymphoma cells (IC50s = 2.7 and 1.3 μM, respectively). It decreases the tumor-initiating subpopulation in DU145 and PC3 cells and halts the cell cycle in the G2/M phase. Darinaparsin decreases transcription of Gli-2, a transcription factor that mediates Sonic hedgehog signaling, when used at a concentration of 1.5 but not 3 μM. It decreases SHP1 phosphatase activity and increases ERK phosphorylation. Darinaparsin reduces tumor growth in DU145 and PC3 prostate cancer mouse xenograft models when administered at a dose of 100 mg/kg every other day.

Uses

Darinaparsin-d5 is the isotope labelled analog of Darinaparsin. Darinaparsin is an arsenic cytotoxin that has been used in pharmacological activities to evaluate the effect on survival an radiosensitivity of tumor cells in vitro under normoxia and hypoxia and in vivo using xenograft models. Darinaparsin has significant and preferential cytotoxic and radiosensitizing effects on solid tumors as compared with normal cells.?? Darinaparsin may therefore increase the therapeutic index of radiation therapy and has near term translational potential.

Definition

ChEBI: (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-(dimethylarsinothio)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid is a peptide.

Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl- Preparation Products And Raw materials

Raw materials

Preparation Products

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Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl- Suppliers

China 23 India 1 United Kingdom 1 United States 3 Global 28
Alabiotech Inc.
Tel
001-619-354-5251
Fax
001-855-855-6087
Email
sales@alabiotech-e.com
Country
United States
ProdList
972
Advantage
60
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

69819-86-9, Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl-Related Search:


  • Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl-
  • ZIO 101
  • Darinaparsin
  • Selurampanel
  • EOS-60608
  • Darinaparsin (ZIO101
  • SP02)
  • Dimethylarsinic glutathione
  • 69819-86-9
  • C12H22AsN3O6S