Ethyl 4-BroMo-2-fluorobenzoate
- Product Name
- Ethyl 4-BroMo-2-fluorobenzoate
- CAS No.
- 474709-71-2
- Chemical Name
- Ethyl 4-BroMo-2-fluorobenzoate
- Synonyms
- Ethyl 4-BroMo-2-fluorobenzoate;2-Fluoro-4-bromobenzoicacid ethyl ester;Benzoic acid, 4-bromo-2-fluoro-, ethyl ester
- CBNumber
- CB42563446
- Molecular Formula
- C9H8BrFO2
- Formula Weight
- 247.06
- MOL File
- 474709-71-2.mol
Ethyl 4-BroMo-2-fluorobenzoate Property
- Boiling point:
- 287.8±25.0 °C(Predicted)
- Density
- 1.504±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- liquid
- color
- Clear, colourless
- EPA Substance Registry System
- Benzoic acid, 4-bromo-2-fluoro-, ethyl ester (474709-71-2)
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PC53347
- Product name
- Ethyl4-bromo-2-fluorobenzoate
- Packaging
- 1g
- Price
- $24
- Updated
- 2021/12/16
- Product number
- 2623-B-33
- Product name
- Ethyl 4-bromo-2-fluorobenzoate
- Packaging
- 1g
- Price
- $31
- Updated
- 2021/12/16
- Product number
- PC53347
- Product name
- Ethyl4-bromo-2-fluorobenzoate
- Packaging
- 5g
- Price
- $73
- Updated
- 2021/12/16
- Product number
- 2623-B-33
- Product name
- Ethyl 4-bromo-2-fluorobenzoate
- Packaging
- 5G
- Price
- $87
- Updated
- 2021/12/16
- Product number
- PC53347
- Product name
- Ethyl4-bromo-2-fluorobenzoate
- Packaging
- 25g
- Price
- $225
- Updated
- 2021/12/16
Ethyl 4-BroMo-2-fluorobenzoate Chemical Properties,Usage,Production
Synthesis
64-17-5
112704-79-7
474709-71-2
Step 1. Preparation of ethyl 4-bromo-2-fluorobenzoate To a stirred solution of 4-bromo-2-fluorobenzoic acid (1.50 g, 6.85 mmol) in dichloromethane (DCM, 26.0 mL) was added sequentially 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDCI, 1.60 g, 8.35 mmol), 4-dimethylaminopyridine (DMAP, 130 mg, 1.06 mmol) and anhydrous ethanol (EtOH, 2.00 mL). The reaction mixture was stirred at room temperature for 20 h and then washed with water and saturated saline in turn. The organic phase was dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (SiO2) with petroleum ether/ethyl acetate (1:5, v/v) as eluent to afford the target product ethyl 4-bromo-2-fluorobenzoate (1.52 g, 90% yield) as a colorless oil. 1H NMR (400 MHz, CDCl3) δ 1.39 (3H, t, J = 6.8 Hz), 4.39 (2H, q, J = 6.8 Hz), 7.32-7.37 (2H, m), 7.80-7.84 (1H, m).
References
[1] Patent: US2012/53180, 2012, A1. Location in patent: Page/Page column 29
[2] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 12, p. 1207 - 1212
[3] Patent: WO2006/34491, 2006, A2. Location in patent: Page/Page column 119-120
[4] Patent: EP2857400, 2015, A1. Location in patent: Paragraph 0880
[5] Patent: CN105712928, 2016, A. Location in patent: Paragraph 0176; 0177
Ethyl 4-BroMo-2-fluorobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 4-BroMo-2-fluorobenzoate manufacturers
- Product
- Ethyl 4-BroMo-2-fluorobenzoate 474709-71-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 50mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-08
- Product
- Ethyl 4-BroMo-2-fluorobenzoate 474709-71-2
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-17