2-(2-Bromophenyl)-2-methylpropanenitrile
- Product Name
- 2-(2-Bromophenyl)-2-methylpropanenitrile
- CAS No.
- 57775-06-1
- Chemical Name
- 2-(2-Bromophenyl)-2-methylpropanenitrile
- Synonyms
- 2-(2-Bromophenyl)-2-methylpropanenitrile;2-(2-Bromo-phenyl)-2-methyl-propionitrile;Benzeneacetonitrile, 2-bromo-α,α-dimethyl-
- CBNumber
- CB42563754
- Molecular Formula
- C10H10BrN
- Formula Weight
- 224.1
- MOL File
- 57775-06-1.mol
2-(2-Bromophenyl)-2-methylpropanenitrile Property
- Boiling point:
- 95-105 °C(Press: 0.03 Torr)
- Density
- 1.352±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B698388
- Product name
- 2-(2-Bromophenyl)-2-methylpropanenitrile
- Packaging
- 100mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- B698388
- Product name
- 2-(2-Bromophenyl)-2-methylpropanenitrile
- Packaging
- 250mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- V6736
- Product name
- 2-(2-Bromophenyl)-2-methylpropanenitrile
- Packaging
- 5g
- Price
- $651
- Updated
- 2021/12/16
- Product number
- CM253768
- Product name
- 2-(2-Bromophenyl)-2-methylpropanenitrile
- Purity
- 95%
- Packaging
- 1g
- Price
- $153
- Updated
- 2021/12/16
- Product number
- 57775061
- Product name
- 2-(2-Bromophenyl)-2-methylpropanenitrile
- Packaging
- 1g
- Price
- $154.5
- Updated
- 2021/12/16
2-(2-Bromophenyl)-2-methylpropanenitrile Chemical Properties,Usage,Production
Synthesis
1072-85-1
78-82-0
57775-06-1
The general procedure for the synthesis of 2-(2-bromophenyl)-2-methylpropionitrile from o-bromofluorobenzene and isobutyronitrile was as follows: in a Mettler Toledo MiniBlock reaction tube, 0.01 mol of 1-bromo-2-fluorobenzene and a solution of 2-methylpropionitrile prepared from 14 g of formononitrile in 8.5 mL of THF with 160 mL of THF were added separately. Subsequently, an equimolar amount (0.01 mol) of sodium hexamethyldisilanilide (1 M solution in THF) was added as a base to each reaction tube at ambient temperature. The reaction mixture was heated to 65 °C over 1 h, then cooled to ambient temperature and the reaction was quenched with 6 mL of 5% HCl solution. The organic phase was separated and the solvent was removed by evaporation. The crude product was analyzed by gas chromatography (GC)/mass spectrometry (MS) and proton nuclear magnetic resonance (1H-NMR) to give 2-(2-bromophenyl)-2-methylpropanenitrile (5.2% GC/MS yield) and unreacted haloaromatics (76.8%).
References
[1] Patent: US2006/247441, 2006, A1. Location in patent: Page/Page column 17
2-(2-Bromophenyl)-2-methylpropanenitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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